Symptomatic 5-fluorouracil-induced sinus bradycardia

5‐Fluorouracil (5‐FU) is a commonly used anti‐neoplastic agent. 5‐FU has been not uncommonly associated with cardiotoxicity, although the many potentially causative mechanisms are yet to be established. Here, we present the case of a 61‐year‐old gemstone miner who developed symptomatic sinus bradyca...

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Bibliographic Details
Published in:Internal medicine journal 2011-07, Vol.41 (7), p.566-570
Main Authors: Lee, A. D., McKay, M. J.
Format: Article
Language:English
Subjects:
Antimetabolites, Antineoplastic - adverse effects
Antimetabolites, Antineoplastic - therapeutic use
Arrhythmia, Sinus - chemically induced
Arrhythmia, Sinus - diagnosis
Arrhythmia, Sinus - physiopathology
bradycardia
Bradycardia - chemically induced
Bradycardia - physiopathology
dizziness
drug toxicity
fluorouracil
Fluorouracil - adverse effects
Fluorouracil - therapeutic use
Humans
Infusions, Intravenous
Male
Middle Aged
pharmacological phenomena
Rectal Neoplasms - complications
Rectal Neoplasms - drug therapy
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Summary:5‐Fluorouracil (5‐FU) is a commonly used anti‐neoplastic agent. 5‐FU has been not uncommonly associated with cardiotoxicity, although the many potentially causative mechanisms are yet to be established. Here, we present the case of a 61‐year‐old gemstone miner who developed symptomatic sinus bradycardia while receiving a continuous 5‐FU infusion combined with radiotherapy for locally advanced rectal cancer. This dysrhythmia is an unusual type of 5‐FU toxicity, our case being the second described. We review the actions of 5‐FU and the various proposed mechanisms of its cardiotoxic effects.
ISSN:1444-0903
1445-5994
DOI:10.1111/j.1445-5994.2011.02523.x