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High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study

To determine the proportion of noncardiac surgery patients exceeding the published 99th percentile or change criteria with the high sensitivity Troponin T (hs-TnT) assay. We measured hs-TnT preoperatively and postoperatively on days 1, 2 and 3 in 325 adults. Postoperatively 45% (95% CI: 39–50%) of p...

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Published in:Clinical biochemistry 2011-08, Vol.44 (12), p.1021-1024
Main Authors: Kavsak, Peter A., Walsh, Mike, Srinathan, Sadeesh, Thorlacius, Laurel, Buse, Giovanna Lurati, Botto, Fernando, Pettit, Shirley, McQueen, Matthew J., Hill, Stephen A., Thomas, Sabu, Mrkobrada, Marko, Alonso-Coello, Pablo, Berwanger, Otavio, Biccard, Bruce M., Cembrowski, George, Chan, Matthew T.V., Chow, Clara K., de Miguel, Angeles, Garcia, Mercedes, Graham, Michelle M., Jacka, Michael J., Kueh, J.H., Li, Stephen C.H., Lit, Lydia C.W., Martínez-Brú, Cecília, Naidoo, Prebashini, Nagele, Peter, Pearse, Rupert M., Rodseth, Reitze N., Sessler, Daniel I., Sigamani, Alben, Szczeklik, Wojciech, Tiboni, Maria, Villar, Juan Carlos, Wang, C.Y., Xavier, Denis, Devereaux, P.J.
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Language:English
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Summary:To determine the proportion of noncardiac surgery patients exceeding the published 99th percentile or change criteria with the high sensitivity Troponin T (hs-TnT) assay. We measured hs-TnT preoperatively and postoperatively on days 1, 2 and 3 in 325 adults. Postoperatively 45% (95% CI: 39–50%) of patients had hs-TnT ≥ 14 ng/L and 22% (95% CI:17–26%) had an elevation (≥ 14 ng/L) and change (> 85%) in hs-TnT. Further research is needed to inform the optimal hs-TnT threshold and change in this setting.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2011.05.017