Aurothiomalate as Preventive and Chain-Breaking Antioxidant in Radical Degradation of High-Molar-Mass Hyaluronan

The potential anti‐ or pro‐oxidative effects of a disease‐modifying antirheumatic drug, aurothiomalate, to protect high‐molar‐mass hyaluronan against radical degradation were investigated along with L‐glutathione – tested in similar functions. Hyaluronan degradation was induced by the oxidative syst...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry & biodiversity 2011-07, Vol.8 (7), p.1274-1283
Main Authors: Valachová, Katarína, Vargová, Andrea, Rapta, Peter, Hrabárová, Eva, Dráfi, František, Bauerová, Katarína, Juránek, Ivo, Šoltés, Ladislav
Format: Article
Language:English
Subjects:
Antioxidant activity
Antioxidants - pharmacology
Antirheumatic activity
Antirheumatic Agents - pharmacology
Aurothiomalate
Benzothiazoles
Carbohydrate Sequence
Glutathione - pharmacology
Gold Sodium Thiomalate - pharmacology
GoldIthiol drug
Hyaluronic Acid - chemistry
Hyaluronic Acid - metabolism
l-Glutathione
Molecular Sequence Data
Oxidation-Reduction - drug effects
Reactive oxygen species (ROS)
Reactive Oxygen Species - metabolism
Sulfonic Acids - metabolism
Thiazoles - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The potential anti‐ or pro‐oxidative effects of a disease‐modifying antirheumatic drug, aurothiomalate, to protect high‐molar‐mass hyaluronan against radical degradation were investigated along with L‐glutathione – tested in similar functions. Hyaluronan degradation was induced by the oxidative system CuII plus ascorbate known as the Weissberger's oxidative system. The time‐ and dose‐dependent changes of the dynamic viscosity of the hyaluronan solutions were studied by the method of rotational viscometry. Additionally, the antioxidative activity of aurothiomalate expressed as a radical‐scavenging capacity based on a decolorization 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) assay was inspected. At the higher concentrations tested, L‐glutathione showed excellent scavenging of .OH and peroxyl‐type radicals, however, at the lowest concentration applied, its pro‐oxidative effect was revealed. The effects of aurothiomalate on hyaluronan degradation were similar to that of L‐glutathione, however, at the lowest concentration tested, no significant pro‐oxidant effect was observed.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201000351