Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development

The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the orientation of the axis of division and cell fate choices in classical models of asymmetric cell division. We then discu...

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Bibliographic Details
Published in:Developmental cell 2011-07, Vol.21 (1), p.102-119
Main Authors: Morin, Xavier, Bellaïche, Yohanns
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell cycle, cell proliferation
Cell differentiation, maturation, development, hematopoiesis
Cell Division - genetics
Cell Lineage
Cell physiology
Cells - cytology
Cells - metabolism
Developmental Biology
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Spindle Apparatus - genetics
Spindle Apparatus - metabolism
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Summary:The orientation of the mitotic spindle has been proposed to control cell fate choices, tissue architecture, and tissue morphogenesis. Here, we review the mechanisms regulating the orientation of the axis of division and cell fate choices in classical models of asymmetric cell division. We then discuss the mechanisms of mitotic spindle orientation in symmetric cell divisions and its possible implications in tissue morphogenesis. Many recent studies show that future advances in the field of mitotic spindle orientation will arise from combinations of physical perturbation and modeling with classical genetics and developmental biology approaches.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2011.06.012