Calcium phosphate bone cement: a possible alternative to autologous bone graft. A radiological and biomechanical comparison in rat tibial bone

Background Donor site morbidity is a problem after autologous bone transplantation. An injectable CaP bone cement indicates properties similar to bone. Materials and methods Double osteotomies on rat tibias were performed. The intercalated segments were avascular (10), vascular (10), or avascular wi...

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Published in:Archives of orthopaedic and trauma surgery 2011-08, Vol.131 (8), p.1035-1041
Main Authors: Winge, Mona I., Reikerås, Olav, Røkkum, Magne
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Animals
Biomechanical Phenomena
Biomechanics
Bone Cements
Bone Transplantation
Calcium Phosphates
Cement
Fracture Fixation - methods
Fractures, Bone - surgery
Male
Medicine
Medicine & Public Health
Orthopaedic Surgery
Orthopedics
Osteotomy
Random Allocation
Rats
Rats, Wistar
Reconstructive Surgical Procedures - methods
Skin & tissue grafts
Tibia - diagnostic imaging
Tibia - injuries
Tibia - surgery
Tomography, X-Ray Computed
Torsion, Mechanical
Transplantation, Autologous
Wound Healing
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Summary:Background Donor site morbidity is a problem after autologous bone transplantation. An injectable CaP bone cement indicates properties similar to bone. Materials and methods Double osteotomies on rat tibias were performed. The intercalated segments were avascular (10), vascular (10), or avascular with Norian SRS ® CaP bone cement replacing cancellous bone (10). Controls were non-operated contralateral tibias (15). All osteotomies were stabilised with an intra-medullary nail. After 8 weeks, all rats were killed. The harvested tibias were compared using X-ray, DEXA scanning, microCT scans and a biomechanical torsional test. Results No difference in healing processes or biomechanical results has been found between the avascular bone graft, vascular bone graft and CaP bone cement groups. Conclusion The injectable CaP bone cement confirms its similarities to bone, implying that it can be used as an adjunct to secure bone fragments and as a possible alternative to autologous bone transplantation in clinical practice.
ISSN:0936-8051
1434-3916
DOI:10.1007/s00402-011-1271-z