The Mutational Profile of Sporadic Epithelial Ovarian Carcinoma

Mutations occurring in sporadic epithelial ovarian carcinomas are reviewed and their functional significance in terms of prognosis and prediction of anticancer drug activity are discussed. Alterations in the BRCA1/2 genes, TP53, PTEN, PI3Kinase, KRAS/BRAF and CTNNB1 are described. TP53 is likely to...

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Bibliographic Details
Published in:Anticancer research 2011-08, Vol.31 (8), p.2661-2668
Main Authors: KALAMANATHAN, S, BATES, V, LORD, R, GREEN, J. A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Female
Female genital diseases
Genes, BRCA1
Genes, BRCA2
Genes, p53
Genes, ras
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Mutation
Neoplasms, Glandular and Epithelial - genetics
Ovarian Neoplasms - genetics
Phosphatidylinositol 3-Kinases - genetics
Proto-Oncogene Proteins B-raf - genetics
Proto-Oncogene Proteins c-akt - genetics
Tumors
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Summary:Mutations occurring in sporadic epithelial ovarian carcinomas are reviewed and their functional significance in terms of prognosis and prediction of anticancer drug activity are discussed. Alterations in the BRCA1/2 genes, TP53, PTEN, PI3Kinase, KRAS/BRAF and CTNNB1 are described. TP53 is likely to be a driver in high grade serous tumours, but is less useful than BRCA status in prediction of response to the platinum or PARPi agents. It is expected that mutation profiling will become integrated into current morphological/immunohistochemical primary diagnostic assessment of tumours once the cost and quality control issues of the technology are addressed.
ISSN:0250-7005
1791-7530