Genetic polymorphism of glutathione S-transferase M1 and T1 in Delhi population of Northern India

Abstract Glutathione S-transferases (GSTs), protect cells from reactive chemical intermediates and oxidative stress. Among different classes of GSTs, GSTM1 (Mu) and GSTT1 (theta) are found to be genetically deleted. Present study was intended to genotype homozygous null distribution of GSTM1 and GST...

Full description

Saved in:
Bibliographic Details
Published in:Environmental toxicology and pharmacology 2009-07, Vol.28 (1), p.25-29
Main Authors: Singh, Satyender, Kumar, Vivek, Thakur, Sachin, Banerjee, Basu Dev, Grover, Shyam Sunder, Rawat, Devender Singh, Pasha, Syed Tazeen, Jain, Sudhir Kumar, Lal, Shiv, Rai, Arvind
Format: Article
Language:English
Subjects:
Emergency
Glutathione S-transferase
North India
Phase-II enzymes
PM10
Polymorphism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c441t-b75fe24d96a45f4d997fd9f8828592916b01d493ad00e107eb7d5b23db1648c83
cites cdi_FETCH-LOGICAL-c441t-b75fe24d96a45f4d997fd9f8828592916b01d493ad00e107eb7d5b23db1648c83
container_end_page 29
container_issue 1
container_start_page 25
container_title Environmental toxicology and pharmacology
container_volume 28
creator Singh, Satyender
Kumar, Vivek
Thakur, Sachin
Banerjee, Basu Dev
Grover, Shyam Sunder
Rawat, Devender Singh
Pasha, Syed Tazeen
Jain, Sudhir Kumar
Lal, Shiv
Rai, Arvind
description Abstract Glutathione S-transferases (GSTs), protect cells from reactive chemical intermediates and oxidative stress. Among different classes of GSTs, GSTM1 (Mu) and GSTT1 (theta) are found to be genetically deleted. Present study was intended to genotype homozygous null distribution of GSTM1 and GSTT1 in healthy individuals of Delhi, located in Northern India. Out of 309 healthy individuals included in this study, we have found genetic deletion in 21% and 27.4%, GSTM1 and GSTT1 genes, respectively. A small proportion (0.7%) population showed deletion of both the genes. The prevalence of the GSTM1* 0/0 and GSTT1* 0/0 genotypes varied within India compared to communities in Chinese, Japanese, Korean and Caucasian.
doi_str_mv 10.1016/j.etap.2009.01.010
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_879102991</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S138266890900026X</els_id><sourcerecordid>879102991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-b75fe24d96a45f4d997fd9f8828592916b01d493ad00e107eb7d5b23db1648c83</originalsourceid><addsrcrecordid>eNp9ks2LFDEQxRtR3A_9BzxITnrqsZL-SAIiyKrrwqqHXcFbSCfVTsaepE3Swvz3m2ZWDx4WCqoOv_cO71VVvaCwoUD7N7sNZj1vGIDcAC0Dj6pTKjirOXD-uNyNYHXfC3lSnaW0A6Bd04in1QmjXDSSi9NKX6LH7AyZw3TYhzhvXdqTMJKf05J13rrgkdzUOWqfRow6IflCifaW3FLiPPmA09YV8bxMOhd4lX4NMW8xenLlrdPPqiejnhI-v9_n1fdPH28vPtfX3y6vLt5f16Ztaa4H3o3IWit73XZj2ZKPVo5CMNFJJmk_ALWtbLQFQAocB267gTV2oH0rjGjOq9dH3zmG3wumrPYuGZwm7TEsSQkuKTApaSFfPUgy4G0r6WrJjqCJIaWIo5qj2-t4UBTUWoHaqbUCtVaggJaBInp5774Me7T_JH8zL8DbI4AljT8Oo0rGoTdoXUSTlQ3uYf93_8nN5LwzevqFB0y7sERfclZUJaZA3axPsP4ASABg_Y_mDjyzrAM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20744918</pqid></control><display><type>article</type><title>Genetic polymorphism of glutathione S-transferase M1 and T1 in Delhi population of Northern India</title><source>ScienceDirect Journals</source><creator>Singh, Satyender ; Kumar, Vivek ; Thakur, Sachin ; Banerjee, Basu Dev ; Grover, Shyam Sunder ; Rawat, Devender Singh ; Pasha, Syed Tazeen ; Jain, Sudhir Kumar ; Lal, Shiv ; Rai, Arvind</creator><creatorcontrib>Singh, Satyender ; Kumar, Vivek ; Thakur, Sachin ; Banerjee, Basu Dev ; Grover, Shyam Sunder ; Rawat, Devender Singh ; Pasha, Syed Tazeen ; Jain, Sudhir Kumar ; Lal, Shiv ; Rai, Arvind</creatorcontrib><description>Abstract Glutathione S-transferases (GSTs), protect cells from reactive chemical intermediates and oxidative stress. Among different classes of GSTs, GSTM1 (Mu) and GSTT1 (theta) are found to be genetically deleted. Present study was intended to genotype homozygous null distribution of GSTM1 and GSTT1 in healthy individuals of Delhi, located in Northern India. Out of 309 healthy individuals included in this study, we have found genetic deletion in 21% and 27.4%, GSTM1 and GSTT1 genes, respectively. A small proportion (0.7%) population showed deletion of both the genes. The prevalence of the GSTM1* 0/0 and GSTT1* 0/0 genotypes varied within India compared to communities in Chinese, Japanese, Korean and Caucasian.</description><identifier>ISSN: 1382-6689</identifier><identifier>EISSN: 1872-7077</identifier><identifier>DOI: 10.1016/j.etap.2009.01.010</identifier><identifier>PMID: 21783978</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Emergency ; Glutathione S-transferase ; North India ; Phase-II enzymes ; PM10 ; Polymorphism</subject><ispartof>Environmental toxicology and pharmacology, 2009-07, Vol.28 (1), p.25-29</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>Copyright © 2009 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-b75fe24d96a45f4d997fd9f8828592916b01d493ad00e107eb7d5b23db1648c83</citedby><cites>FETCH-LOGICAL-c441t-b75fe24d96a45f4d997fd9f8828592916b01d493ad00e107eb7d5b23db1648c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21783978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Satyender</creatorcontrib><creatorcontrib>Kumar, Vivek</creatorcontrib><creatorcontrib>Thakur, Sachin</creatorcontrib><creatorcontrib>Banerjee, Basu Dev</creatorcontrib><creatorcontrib>Grover, Shyam Sunder</creatorcontrib><creatorcontrib>Rawat, Devender Singh</creatorcontrib><creatorcontrib>Pasha, Syed Tazeen</creatorcontrib><creatorcontrib>Jain, Sudhir Kumar</creatorcontrib><creatorcontrib>Lal, Shiv</creatorcontrib><creatorcontrib>Rai, Arvind</creatorcontrib><title>Genetic polymorphism of glutathione S-transferase M1 and T1 in Delhi population of Northern India</title><title>Environmental toxicology and pharmacology</title><addtitle>Environ Toxicol Pharmacol</addtitle><description>Abstract Glutathione S-transferases (GSTs), protect cells from reactive chemical intermediates and oxidative stress. Among different classes of GSTs, GSTM1 (Mu) and GSTT1 (theta) are found to be genetically deleted. Present study was intended to genotype homozygous null distribution of GSTM1 and GSTT1 in healthy individuals of Delhi, located in Northern India. Out of 309 healthy individuals included in this study, we have found genetic deletion in 21% and 27.4%, GSTM1 and GSTT1 genes, respectively. A small proportion (0.7%) population showed deletion of both the genes. The prevalence of the GSTM1* 0/0 and GSTT1* 0/0 genotypes varied within India compared to communities in Chinese, Japanese, Korean and Caucasian.</description><subject>Emergency</subject><subject>Glutathione S-transferase</subject><subject>North India</subject><subject>Phase-II enzymes</subject><subject>PM10</subject><subject>Polymorphism</subject><issn>1382-6689</issn><issn>1872-7077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9ks2LFDEQxRtR3A_9BzxITnrqsZL-SAIiyKrrwqqHXcFbSCfVTsaepE3Swvz3m2ZWDx4WCqoOv_cO71VVvaCwoUD7N7sNZj1vGIDcAC0Dj6pTKjirOXD-uNyNYHXfC3lSnaW0A6Bd04in1QmjXDSSi9NKX6LH7AyZw3TYhzhvXdqTMJKf05J13rrgkdzUOWqfRow6IflCifaW3FLiPPmA09YV8bxMOhd4lX4NMW8xenLlrdPPqiejnhI-v9_n1fdPH28vPtfX3y6vLt5f16Ztaa4H3o3IWit73XZj2ZKPVo5CMNFJJmk_ALWtbLQFQAocB267gTV2oH0rjGjOq9dH3zmG3wumrPYuGZwm7TEsSQkuKTApaSFfPUgy4G0r6WrJjqCJIaWIo5qj2-t4UBTUWoHaqbUCtVaggJaBInp5774Me7T_JH8zL8DbI4AljT8Oo0rGoTdoXUSTlQ3uYf93_8nN5LwzevqFB0y7sERfclZUJaZA3axPsP4ASABg_Y_mDjyzrAM</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Singh, Satyender</creator><creator>Kumar, Vivek</creator><creator>Thakur, Sachin</creator><creator>Banerjee, Basu Dev</creator><creator>Grover, Shyam Sunder</creator><creator>Rawat, Devender Singh</creator><creator>Pasha, Syed Tazeen</creator><creator>Jain, Sudhir Kumar</creator><creator>Lal, Shiv</creator><creator>Rai, Arvind</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Genetic polymorphism of glutathione S-transferase M1 and T1 in Delhi population of Northern India</title><author>Singh, Satyender ; Kumar, Vivek ; Thakur, Sachin ; Banerjee, Basu Dev ; Grover, Shyam Sunder ; Rawat, Devender Singh ; Pasha, Syed Tazeen ; Jain, Sudhir Kumar ; Lal, Shiv ; Rai, Arvind</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-b75fe24d96a45f4d997fd9f8828592916b01d493ad00e107eb7d5b23db1648c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Emergency</topic><topic>Glutathione S-transferase</topic><topic>North India</topic><topic>Phase-II enzymes</topic><topic>PM10</topic><topic>Polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Satyender</creatorcontrib><creatorcontrib>Kumar, Vivek</creatorcontrib><creatorcontrib>Thakur, Sachin</creatorcontrib><creatorcontrib>Banerjee, Basu Dev</creatorcontrib><creatorcontrib>Grover, Shyam Sunder</creatorcontrib><creatorcontrib>Rawat, Devender Singh</creatorcontrib><creatorcontrib>Pasha, Syed Tazeen</creatorcontrib><creatorcontrib>Jain, Sudhir Kumar</creatorcontrib><creatorcontrib>Lal, Shiv</creatorcontrib><creatorcontrib>Rai, Arvind</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Satyender</au><au>Kumar, Vivek</au><au>Thakur, Sachin</au><au>Banerjee, Basu Dev</au><au>Grover, Shyam Sunder</au><au>Rawat, Devender Singh</au><au>Pasha, Syed Tazeen</au><au>Jain, Sudhir Kumar</au><au>Lal, Shiv</au><au>Rai, Arvind</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic polymorphism of glutathione S-transferase M1 and T1 in Delhi population of Northern India</atitle><jtitle>Environmental toxicology and pharmacology</jtitle><addtitle>Environ Toxicol Pharmacol</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>28</volume><issue>1</issue><spage>25</spage><epage>29</epage><pages>25-29</pages><issn>1382-6689</issn><eissn>1872-7077</eissn><abstract>Abstract Glutathione S-transferases (GSTs), protect cells from reactive chemical intermediates and oxidative stress. Among different classes of GSTs, GSTM1 (Mu) and GSTT1 (theta) are found to be genetically deleted. Present study was intended to genotype homozygous null distribution of GSTM1 and GSTT1 in healthy individuals of Delhi, located in Northern India. Out of 309 healthy individuals included in this study, we have found genetic deletion in 21% and 27.4%, GSTM1 and GSTT1 genes, respectively. A small proportion (0.7%) population showed deletion of both the genes. The prevalence of the GSTM1* 0/0 and GSTT1* 0/0 genotypes varied within India compared to communities in Chinese, Japanese, Korean and Caucasian.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21783978</pmid><doi>10.1016/j.etap.2009.01.010</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1382-6689
ispartof Environmental toxicology and pharmacology, 2009-07, Vol.28 (1), p.25-29
issn 1382-6689
1872-7077
language eng
recordid cdi_proquest_miscellaneous_879102991
source ScienceDirect Journals
subjects Emergency
Glutathione S-transferase
North India
Phase-II enzymes
PM10
Polymorphism
title Genetic polymorphism of glutathione S-transferase M1 and T1 in Delhi population of Northern India
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T17%3A09%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20polymorphism%20of%20glutathione%20S-transferase%20M1%20and%20T1%20in%20Delhi%20population%20of%20Northern%20India&rft.jtitle=Environmental%20toxicology%20and%20pharmacology&rft.au=Singh,%20Satyender&rft.date=2009-07-01&rft.volume=28&rft.issue=1&rft.spage=25&rft.epage=29&rft.pages=25-29&rft.issn=1382-6689&rft.eissn=1872-7077&rft_id=info:doi/10.1016/j.etap.2009.01.010&rft_dat=%3Cproquest_cross%3E879102991%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c441t-b75fe24d96a45f4d997fd9f8828592916b01d493ad00e107eb7d5b23db1648c83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=20744918&rft_id=info:pmid/21783978&rfr_iscdi=true