Maternal serum IGF-I, IGFBP-1 and IGFBP-3 at 11–13 weeks in trisomy 21 and trisomy 18 pregnancies

• Published in: European journal of obstetrics & gynecology and reproductive biology 2011-08, Vol.157 (2), p.166-168
• Main Authors: Sifakis, Stavros, Akolekar, Ranjit, Kappou, Dimitra, Mantas, Nikitas, Nicolaides, Kypros H
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Biomarkers - blood; Case-Control Studies; Chorionic Gonadotropin, beta Subunit, Human - blood; Chromosome aberrations; Chromosomes, Human, Pair 18; Down Syndrome - diagnosis; Female; Gynecology. Andrology. Obstetrics; Humans; Insulin-Like Growth Factor Binding Protein 1 - blood; Insulin-Like Growth Factor Binding Protein 3 - blood; Insulin-like growth factor binding protein-1; Insulin-like growth factor binding protein-3; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factor-I; Maternal Age; Medical genetics; Medical sciences; Nuchal Translucency Measurement; Obstetrics and Gynecology; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First - blood; Pregnancy-Associated Plasma Protein-A - metabolism; Prenatal Diagnosis - methods; Prenatal screening; Sensitivity and Specificity; Trisomy - diagnosis; Trisomy 18; Trisomy 21
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/j.ejogrb.2011.03.029

Abstract Objective To investigate the possible value of maternal serum concentration of insulin-like growth factor-I (IGF-I), IGF binding protein-1 (IGFBP-1) and IGFBP-3 in first-trimester screening for fetal aneuploidies. Study design Maternal serum concentrations of IGF-I, IGFBP-1 and IGFBP-3 at 11–13 weeks of gestation were measured and compared in 30 trisomy 21, 30 trisomy 18 and 120 euploid pregnancies. Results The median multiple of the normal median (MoM) values of maternal serum IGF-I, IGFBP-1 and IGFBP-3 in trisomy 21, trisomy 18 and euploid pregnancies were not significantly different (IGF-I: 1.10, 1.14 and 1.0 MoM, respectively; IGFBP-1: 1.10, 1.01 and 1.0 MoM; IGFBP-3: 0.90, 1.16 and 0.98 MoM). Conclusion Measurement of maternal serum IGF-I, IGFBP-1 and IGFBP-3 at 11–13 weeks of gestation is unlikely to be useful in screening for trisomies 21 and 18.