Interaction profile for lead, manganese, zinc, and copper

This interaction profile discusses and evaluates the evidence for joint toxic action among lead, manganese, zinc, and copper. The interaction profile recommends how to incorporate concerns about possible interactions or additivity into public health assessments of hazardous waste sites where people...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2004-12, Vol.18 (3), p.231-234
Main Authors: Roney, Nickolette, Colman, Joan
Format: Article
Language:English
Subjects:
Chemical mixtures
Copper
Lead
Manganese
Risk assessment
Zinc
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Summary:This interaction profile discusses and evaluates the evidence for joint toxic action among lead, manganese, zinc, and copper. The interaction profile recommends how to incorporate concerns about possible interactions or additivity into public health assessments of hazardous waste sites where people might be exposed to mixtures of these chemicals. The profile recommends using endpoint-specific hazard indexes and a hazard quotient to screen for potential health effects. The qualitative weight-of-evidence (WOE) approach is then used to predict the impact of interactions on the endpoint-specific hazard indexes and hazard quotient.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2004.01.008