Murine Cecal Patch M Cells Transport Infectious Prions In Vivo

We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of ce...

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Bibliographic Details
Published in:The Journal of infectious diseases 2010-12, Vol.202 (12), p.1916-1919
Main Authors: Foster, Neil, Macpherson, Gordon G.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Biological and medical sciences
Cecum
Cecum - cytology
Cecum - immunology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Enterocytes
Female
Fundamental and applied biological sciences. Psychology
Infections
Infectious diseases
Inoculation
Intestines
Lectins
Medical sciences
Mice
Mice, Inbred BALB C
Microbiology
Neurology
Non conventional transmissible agents
Peyer's Patches - physiology
Peyers patches
Prions
Prions - metabolism
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Summary:We show that following oral inoculation, prions bind to ileal Peyer patch and cecal patch microfold cells (M cells) in vivo. Furthermore, we show evidence that the cecum acts a biological sump holding large concentrations of prions for relatively long periods, thus increasing the exposure time of cecal patch M cells. Our results show a critical initial step in the translocation of prions from the intestinal lumen of mammals in vivo, which is a precursor to infection.
ISSN:0022-1899
1537-6613
DOI:10.1086/657415