Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics

Sodium dodecylbenzenesulfonate is one of a group of salts of alkylbenzene sulfonates used in cosmetics as surfactant-cleansing agents. Sodium dodecylbenzenesulfonate is soluble in water and partially soluble in alcohol, with dermal absorption dependent on pH. Dodecylbenzenesulfonate salts are not to...

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Bibliographic Details
Published in:International journal of toxicology 2010-11, Vol.29 (6_suppl), p.288S-305S
Main Authors: Becker, Lillian C., Bergfeld, Wilma F., Belsito, Donald V., Hill, Ronald A., Klaassen, Curtis D., Liebler, Daniel C., Marks, James G., Shank, Ronald C., Slaga, Thomas J., Snyder, Paul W., Andersen, F. Alan
Format: Article
Language:English
Subjects:
Alkanesulfonic Acids - adverse effects
Alkanesulfonic Acids - chemistry
Animals
Benzenesulfonates - chemistry
Benzenesulfonates - toxicity
Chemical Phenomena
Consumer Product Safety
Cosmetics - chemistry
Cosmetics - toxicity
Detergents - chemistry
Detergents - toxicity
Dose-Response Relationship, Drug
Humans
Irritants
Mutagenicity Tests
Rabbits
Skin - metabolism
Surface-Active Agents - chemistry
Surface-Active Agents - toxicity
Toxicity Tests, Acute
Toxicity Tests, Chronic
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Summary:Sodium dodecylbenzenesulfonate is one of a group of salts of alkylbenzene sulfonates used in cosmetics as surfactant-cleansing agents. Sodium dodecylbenzenesulfonate is soluble in water and partially soluble in alcohol, with dermal absorption dependent on pH. Dodecylbenzenesulfonate salts are not toxic in single-dose oral and dermal animal tests, and no systemic toxicities were observed in repeat-dose dermal animal studies. In dermal animal studies, no evidence of reproductive or developmental toxicity was reported. At 15% concentrations, sodium dodecylbenzenesulfonate was severely irritating to rabbit skin. The Cosmetic Ingredient Review Expert Panel concluded that the irritant properties of these ingredients are similar to those of other detergents, with severity dependent on concentration and pH. Products containing these ingredients should be formulated to ensure that the irritancy potential is minimized.
ISSN:1091-5818
1092-874X
DOI:10.1177/1091581810386124