Prolonged Sporadic Hemiplegic Migraine Associated With a Novel De Novo Missense ATP1A2 Gene Mutation

Hemiplegic migraine is a rare form of migraine characterized by periodic attacks of migraine with neurologic aura and transient hemiplegia. There are familial and sporadic cases, both on a genetic basis; we describe the case of a 6‐year‐old boy affected by sporadic hemiplegic migraine, showing a nov...

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Bibliographic Details
Published in:Headache 2011-03, Vol.51 (3), p.447-450
Main Authors: De Sanctis, Sara, Grieco, Gaetano Salvatore, Breda, Luciana, Casali, Carlo, Nozzi, Manuela, Del Torto, Marianna, Chiarelli, Francesco, Verrotti, Alberto
Format: Article
Language:English
Subjects:
Anticonvulsants - therapeutic use
ATP1A2
ATP1A2 gene
Biological and medical sciences
Cardiovascular system
Child
Exons
Flunarizine - therapeutic use
Headache
Hemiplegia
Hemiplegia - genetics
Humans
Medical sciences
Migraine
Migraine with Aura - diagnosis
Migraine with Aura - drug therapy
Migraine with Aura - genetics
Missense mutation
Mutation
Mutation, Missense - genetics
Neurology
Pharmacology. Drug treatments
prolonged aura
Sodium-Potassium-Exchanging ATPase - genetics
sporadic hemiplegic migraine
Treatment Outcome
Vascular diseases and vascular malformations of the nervous system
Vasodilator agents. Cerebral vasodilators
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Summary:Hemiplegic migraine is a rare form of migraine characterized by periodic attacks of migraine with neurologic aura and transient hemiplegia. There are familial and sporadic cases, both on a genetic basis; we describe the case of a 6‐year‐old boy affected by sporadic hemiplegic migraine, showing a novel ATP1A2 gene missense mutation (p.Gly715Arg) in exon 16. Long‐term treatment with flunarizine resulted in good clinical response and prevention of further attacks.
ISSN:0017-8748
1526-4610
DOI:10.1111/j.1526-4610.2010.01793.x