Prepregnancy obesity and sFlt1-induced preeclampsia in mice: developmental programming model of metabolic syndrome

Objective We sought to establish a model of fetal programming of metabolic syndrome by exposure to soluble fms-like tyrosine kinase-1 (sFlt1)-induced preeclampsia (PE) and preexisting maternal obesity (MO). Study design CD-1 female mice were placed on either standard or high-fat diet for 3 months. O...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2011-05, Vol.204 (5), p.398.e1-398.e8
Main Authors: Bytautiene, Egle, MD, PhD, Tamayo, Esther, Kechichian, Talar, BS, MS, Drever, Nathan, MD, Gamble, Phyllis, Hankins, Gary D.V., MD, Saade, George R., MD
Format: Article
Language:English
Subjects:
Adiposity
Animals
Biological and medical sciences
Blood Pressure
Diseases of mother, fetus and pregnancy
Female
Fetal Development - physiology
Gynecology. Andrology. Obstetrics
Male
Medical sciences
Metabolic diseases
metabolic syndrome
Metabolic Syndrome - etiology
Metabolic Syndrome - metabolism
Mice
Miscellaneous
Obesity
Obesity - metabolism
Obstetrics and Gynecology
offspring
Other metabolic disorders
Pre-Eclampsia - chemically induced
Pre-Eclampsia - metabolism
preeclampsia
Pregnancy
Pregnancy. Fetus. Placenta
Vascular Endothelial Growth Factor Receptor-1 - pharmacology
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Summary:Objective We sought to establish a model of fetal programming of metabolic syndrome by exposure to soluble fms-like tyrosine kinase-1 (sFlt1)-induced preeclampsia (PE) and preexisting maternal obesity (MO). Study design CD-1 female mice were placed on either standard or high-fat diet for 3 months. On day 8 of pregnancy, mice were injected with either adenovirus-carrying sFlt1 or adenovirus-carrying murine immunoglobulin G2α Fc fragment. Offspring were studied at 6 months of age. Results Exposure to MO with/without PE resulted in significant increase in progeny's weight and adiposity. Blood pressure in males was significantly increased due to MO with PE. Metabolic blood analytes were affected in males and females exposed to only PE or MO with/without PE; inflammatory—in females exposed to MO with/without PE and males born to MO with PE; atherosclerotic—in females exposed to MO. Conclusion Exposure to maternal prepregnancy obesity and sFlt1-induced preeclampsia alter the offspring's blood pressure, metabolic, inflammatory, and atherosclerotic profiles later in life.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2011.02.031