NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus

• Published in: Clinical and experimental pharmacology & physiology 2011-08, Vol.38 (8), p.550-554
• Main Authors: Sheng, Fei-Feng, Dai, Xing-Ping, Qu, Jian, Lei, Guang-Hua, Lu, Hong-Bin, Wu, Jing, Xu, Xiao-Jing, Pei, Qi, Dong, Min, Liu, Ying-Zi, Zhou, Hong-Hao, Liu, Zhao-Qian
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alleles; Asian Continental Ancestry Group - genetics; Carbamates - pharmacology; Carbamates - therapeutic use; Cholesterol - blood; Cholesterol - metabolism; Control Groups; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; efficacy; Female; Genetic Predisposition to Disease - ethnology; Genotype; Humans; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Insulin - blood; Insulin - metabolism; Male; Middle Aged; nicotinamide phosphoribosyltransferase; Nicotinamide Phosphoribosyltransferase - genetics; Piperidines - pharmacology; Piperidines - therapeutic use; polymorphism; Polymorphism, Genetic; Polymorphism, Single Nucleotide; repaglinide; Treatment Outcome; Type 2 diabetes
• ISSN: 0305-1870; 1440-1681
• DOI: 10.1111/j.1440-1681.2011.05548.x

Summary 1. In the present study, we investigated the associations of nicotinamide phosphoribosyltransferase (NAMPT)‐3186 C/T and ‐948G/T polymorphisms with the risk of Type 2 diabetes mellitus (T2DM) and their impact on the efficacy of repaglinide in Chinese Han T2DM patients. 2. In all, 170 patients with T2DM and 129 healthy controls were genotyped for NAMPT‐948G>T and ‐3186C>T polymorphisms. Thirty‐five patients with different NAMPT ‐3186 C/T genotypes and the same organic anion‐transporting polypeptide 1B1 (OATP1B1521) T/C genotype were randomly selected to undergo 8 weeks preprandial repaglinide treatment (1 mg, three times daily). Serum fasting plasma glucose (FPG), post‐prandial plasma glucose (PPG), glycated haemoglobin (HbAlc), fasting serum insulin (FINS), post‐prandial serum insulin (PINS), triglyceride (TG), total cholesterol (CHO), homeostasis model assessment of insulin resistance (HOMA‐IR), low‐density lipoprotein–cholesterol (LDL‐C) and high‐density lipoprotein–cholesterol (HDL‐C) were determined before and after repaglinide treatment. 3. After repaglinide treatment for 8 consecutive weeks, there were significantly decreases in PFG, PPG, HbAlc, CHO and LDL‐C, and increases in FINS, HDL‐C and the HDL‐C : LDL‐C ratio, in T2DM patients. The elevated PINS value in patients with CT genotypes was significantly lower than that in patients with the CC and TT genotypes (P