Cationic Phenylene Ethynylene Polymers and Oligomers Exhibit Efficient Antiviral Activity

The antiviral activities of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using two model viruses, the T4 and MS2 bacteriophages. Under UV/visible light irradiation, significant antiviral activity was observe...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2011-07, Vol.3 (7), p.2209-2214
Main Authors: Wang, Ying, Canady, Taylor D, Zhou, Zhijun, Tang, Yanli, Price, Dominique N, Bear, David G, Chi, Eva Y, Schanze, Kirk S, Whitten, David G
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Alkynes - pharmacology
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Bacteriophage T4 - drug effects
Bacteriophage T4 - pathogenicity
Bacteriophage T4 - ultrastructure
Cations
Cytopathogenic Effect, Viral
Ethers - chemistry
Ethers - pharmacology
Levivirus - drug effects
Levivirus - pathogenicity
Levivirus - ultrastructure
Microscopy, Electron, Transmission
Polymers - chemistry
Polymers - pharmacology
Ultraviolet Rays
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Summary:The antiviral activities of poly(phenylene ethynylene) (PPE)-based cationic conjugated polyelectrolytes (CPE) and oligo-phenylene ethynylenes (OPE) were investigated using two model viruses, the T4 and MS2 bacteriophages. Under UV/visible light irradiation, significant antiviral activity was observed for all of the CPEs and OPEs; without irradiation, most of these compounds exhibited high inactivation activity against the MS2 phage and moderate inactivation ability against the T4 phage. Transmission electron microscopy (TEM) and SDS polyacrylamide gel electrophoresis (SDS-PAGE) reveal that the CPEs and OPEs exert their antiviral activity by partial disassembly of the phage particle structure in the dark and photochemical damage of the phage capsid protein under UV/visible light irradiation.
ISSN:1944-8244
1944-8252
DOI:10.1021/am200575y