Klotho KL-VS genotype is involved in blood pressure regulation

Genome-wide linkage analysis studies reported the importance of the long arm of chromosome 13 in systolic blood pressure regulation. Therefore, isolating a genetic variant related to this chromosomal region could be challenging. Klotho KL-VS allele is located on this chromosomal region and its relat...

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Bibliographic Details
Published in:Clinica chimica acta 2011-09, Vol.412 (19-20), p.1773-1777
Main Authors: Nzietchueng, Rosine, El Shamieh, Said, Benachour, Hamanou, Labat, Carlos, Herbeth, Bernard, Ndiaye, Ndeye Coumba, Masson, Christine, Visvikis-Siest, Sophie, Benetos, Athanase
Format: Article
Language:English
Subjects:
Aged
Antihypertensive treatment
Base Sequence
Blood Pressure - genetics
Cardio-vascular diseases
Cohort Studies
DNA Primers
Female
Genome-Wide Association Study
Genotype
Glucuronidase - genetics
Humans
klotho KL-VS genotype
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism
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Summary:Genome-wide linkage analysis studies reported the importance of the long arm of chromosome 13 in systolic blood pressure regulation. Therefore, isolating a genetic variant related to this chromosomal region could be challenging. Klotho KL-VS allele is located on this chromosomal region and its relationships with cardio-vascular risk factors need extensive investigations. The aim of the present study is to examine whether the klotho KL-VS genotype is associated with cardio-vascular risk factors, more particularly hypertension, in two independent cohorts. A secondary objective was to investigate relationships with antihypertensive treatment, arterial stiffness and carotid artery parameters. A total of 1023 French individuals were genotyped for klotho KL-VS. Participants were part of the French ERA and STANISLAS cohorts. In both cohorts, klotho KL-VS/KL-VS genotype was significantly associated with lower systolic blood pressure and pulse pressure when compared to homozygous and heterozygous more frequent (WT) allele carriers (p=0.003 and p
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2011.05.032