Immunological evaluation of vaginal secretion in patients with high-grade cervical intraepithelial neoplasia treated with intralesional interferon alpha-2b

Conservative treatment with intralesional interferon (IFN) is a therapeutic option for cervical intraepithelial neoplasia (CIN) patients of childbearing age. The study group was made up of patients diagnosed with a high-grade lesion and treated with intralesional human recombinant IFNalpha-2b. Vagin...

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Bibliographic Details
Published in:European journal of gynaecological oncology 2011, Vol.32 (3), p.297-302
Main Authors: Mardegan, M C, Ramos, M C, Adad, S J, Michelin, M A, Shimba, D, Murta, E F C
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Agents - therapeutic use
Cervical Intraepithelial Neoplasia - drug therapy
Cervical Intraepithelial Neoplasia - pathology
Cervical Intraepithelial Neoplasia - virology
Cytokines - secretion
DNA, Viral - analysis
Female
Flow Cytometry
Humans
Interferon-alpha - administration & dosage
Interferon-alpha - therapeutic use
Middle Aged
Papillomaviridae - genetics
Prospective Studies
Recombinant Proteins
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
Vagina - pathology
Vagina - secretion
Vagina - virology
Vaginal Smears
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Summary:Conservative treatment with intralesional interferon (IFN) is a therapeutic option for cervical intraepithelial neoplasia (CIN) patients of childbearing age. The study group was made up of patients diagnosed with a high-grade lesion and treated with intralesional human recombinant IFNalpha-2b. Vaginal secretion was collected during IFNalpha-2b treatment for analysis of cytokines and viral load. The initial histology diagnostic was 62.5% (n = 5) with CIN 2 and 37.5% (n = 3) with CIN 3. In terms of clinical evaluation and anatomopathology, 6.5% (n = 5) had a good clinical response, while 37.5% (n = 3) had therapeutic failure. All the patients with therapeutic failure were smokers. Interleukin 6 and tumor necrosis factor-alpha concentrations were raised at the sixth application for the patient group who failed to respond to therapy compared to the responsive group (p = 0.0357). Patients with a good response exhibited a reduction in human papillomavirus viral load (p = 0.03). Patients that had a good response had lower concentrations of inflammatory cytokines than did non-responders.
ISSN:0392-2936