Hypocholesterolemia is associated negatively with hemolysate lipid peroxidation in sickle cell anemia patients

The oxidative stress levels in plasma and hemolysate and cholesterol levels in plasma of sickle cell anemia patients, carriers and controls were evaluated. A total of 40 cases—17 patients, 13 carriers and 10 controls—were involved in the study. Plasma and hemolysate malondialdehyde (MDA) were detect...

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Bibliographic Details
Published in:Clinical and experimental medicine 2011-09, Vol.11 (3), p.195-198
Main Authors: Yesim, Oztas Er, Suna, Sabuncuoglu, Selma, Unal, Hilal, Ozgunes, Nuriman, Ozgunes
Format: Article
Language:English
Subjects:
Adolescent
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - complications
Biochemistry
Child
Child, Preschool
Cholesterol
Cholesterol - blood
Dyslipidemias - blood
Dyslipidemias - complications
Enzymes
Female
Hematology
Hemolysis
Humans
Internal Medicine
Lipid Peroxidation
Male
Malondialdehyde - blood
Medicine
Medicine & Public Health
Oncology
Oxidative Stress
Short Communication
Sickle cell anemia
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Summary:The oxidative stress levels in plasma and hemolysate and cholesterol levels in plasma of sickle cell anemia patients, carriers and controls were evaluated. A total of 40 cases—17 patients, 13 carriers and 10 controls—were involved in the study. Plasma and hemolysate malondialdehyde (MDA) were detected via thiobarbituric acid reaction with a fluorimetric detector by high-performance liquid chromatography system. Plasma cholesterol was determined by enzymatic colorimetric method. Mean MDA levels of SCA patients were higher than those of the carriers’ and healthy children’s both in plasma and in hemolysate ( P  
ISSN:1591-8890
1591-9528
DOI:10.1007/s10238-010-0124-3