The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)

Summary Background & aims Enteroendocrine cells are thought to directly sense nutrients via α-gustducin coupled taste receptors (originally identified in the oral epithelium) to modulate the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Methods We measured mRNA expression of...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2011-08, Vol.30 (4), p.524-532
Main Authors: Steinert, R.E, Gerspach, A.C, Gutmann, H, Asarian, L, Drewe, J, Beglinger, C
Format: Article
Language:English
Subjects:
Adult
Aged
antagonists
Appetite
Benzene Derivatives - administration & dosage
Biological and medical sciences
colon
Colon - drug effects
Enteroendocrine Cells - secretion
epithelium
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Gastrointestinal satiation peptides
gene expression
Glucagon-Like Peptide 1 - genetics
Glucagon-Like Peptide 1 - secretion
glucose
Glucose - metabolism
Gut
Humans
ileum
Ileum - drug effects
Immunohistochemistry
Intestinal chemosensitivity
Male
messenger RNA
Middle Aged
Nutrient sensing
nutrients
peptide YY
Peptide YY - genetics
Peptide YY - secretion
peptides
proteins
receptors
Receptors, G-Protein-Coupled - antagonists & inhibitors
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
secretion
Sweet taste receptors
Taste
Transducin - antagonists & inhibitors
Transducin - genetics
Transducin - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Summary Background & aims Enteroendocrine cells are thought to directly sense nutrients via α-gustducin coupled taste receptors (originally identified in the oral epithelium) to modulate the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Methods We measured mRNA expression of α-gustducin and T1R3 along the human gut; immunohistochemistry was used to confirm co-localization with GLP-1. Functional implication of sweet taste receptors in glucose-stimulated secretion of GLP-1 and PYY was determined by intragastric infusion of glucose with or without lactisole (a sweet taste receptor antagonist) in 16 healthy subjects. Results α-gustducin was expressed in a region-specific manner (predominantly in the proximal gut and less in ileum and colon, P  
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2011.01.007