Differential conditioned fear response predicts duloxetine treatment outcome in male veterans with PTSD: A pilot study

Abstract This pilot study tested whether posttraumatic stress disorder (PTSD) patients with impaired conditioned fear acquisition were refractory to open-label duloxetine treatment. Patients with a differential conditioned fear response at pre-treatment subsequently demonstrated significant reductio...

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Bibliographic Details
Published in:Psychiatry research 2011-08, Vol.188 (3), p.453-455
Main Authors: Aikins, Deane E, Jackson, Eric D, Christensen, Alicia, Walderhaug, Espen, Afroz, Sonia, Neumeister, Alexander
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Antidepressive Agents - therapeutic use
Anxiety disorders. Neuroses
Biological and medical sciences
Conditioning
Conditioning (Psychology)
Duloxetine
Duloxetine Hydrochloride
Fear
Humans
Male
Medical sciences
Middle Aged
Multivariate Analysis
Neuropharmacology
Pharmacology. Drug treatments
Pilot Projects
Post-traumatic stress disorder
Psychiatry
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
PTSD
Stress Disorders, Post-Traumatic - diagnosis
Stress Disorders, Post-Traumatic - drug therapy
Stress Disorders, Post-Traumatic - psychology
Thiophenes - therapeutic use
Veterans
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Summary:Abstract This pilot study tested whether posttraumatic stress disorder (PTSD) patients with impaired conditioned fear acquisition were refractory to open-label duloxetine treatment. Patients with a differential conditioned fear response at pre-treatment subsequently demonstrated significant reductions in PTSD symptoms. These data provide initial evidence of a putative biomarker of selective treatment response in PTSD.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2011.05.009