Carbon nanohorns accelerate bone regeneration in rat calvarial bone defect

A recent study showed that carbon nanohorns (CNHs) have biocompatibility and possible medical uses such as in drug delivery systems. It was reported that some kinds of carbon nanomaterials such as carbon nanotubes were useful for bone formation. However, the effect of CNHs on bone tissue has not bee...

Full description

Saved in:
Bibliographic Details
Published in:Nanotechnology 2011-02, Vol.22 (6), p.065102-065102
Main Authors: Kasai, Takao, Matsumura, Sachiko, Iizuka, Tadashi, Shiba, Kiyotaka, Kanamori, Takeshi, Yudasaka, Masako, Iijima, Sumio, Yokoyama, Atsuro
Format: Article
Language:English
Subjects:
Animals
Bone Diseases - drug therapy
Bone Diseases - surgery
Bone Regeneration - drug effects
Bones
Carbon
Disease Models, Animal
Ethyl alcohol
Guided Tissue Regeneration - methods
Histocytochemistry
Macrophages
Male
Materials Testing
Membranes
Microscopy, Electron, Transmission
Nanomaterials
Nanostructure
Nanotubes, Carbon - chemistry
Rats
Rats, Wistar
Regeneration
Skull - drug effects
Skull - physiology
Skull - surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A recent study showed that carbon nanohorns (CNHs) have biocompatibility and possible medical uses such as in drug delivery systems. It was reported that some kinds of carbon nanomaterials such as carbon nanotubes were useful for bone formation. However, the effect of CNHs on bone tissue has not been clarified. The purpose of this study was to evaluate the effect of CNHs on bone regeneration and their possible application for guided bone regeneration (GBR). CNHs dispersed in ethanol were fixed on a porous polytetrafluoroethylene membrane by vacuum filtration. Cranial defects were created in rats and covered by a membrane with/without CNHs. At two weeks, bone formation under the membrane with CNHs had progressed more than under that without CNHs and numerous macrophages were observed attached to CNHs. At eight weeks, there was no significant difference in the amount of newly formed bone between the groups and the appearance of macrophages was decreased compared with that at two weeks. Newly formed bone attached to some CNHs directly. These results suggest that macrophages induced by CNHs are related to bone regeneration. In conclusion, the present study indicates that CNHs are compatible with bone tissue and effective as a material for GBR.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/22/6/065102