Preparation of albumin-PAA nanocapsules and their controlled release behavior for drugs

New kinds of narrowly distributed protein‐based nanoparticles, bovine serum albumin‐Poly (acrylic acid) (BSA/PAA) nanospheres, and nanocapsules were prepared via in situ polymerization, swelling, and re‐aggregation. The structure and morphology of the nanospheres were characterized by UV‐Vis, FT‐IR,...

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Published in:Polymers for advanced technologies 2010-10, Vol.21 (10), p.685-690
Main Authors: Wang, Rong-Min, Li, Gang, Zhang, Hui-Fang, He, Yu-Feng, He, Nai-Pu, Lei, Ziqiang
Format: Article
Language:English
Subjects:
Acrylic acid
biopolymer nanocapsules
Biopolymers
bovine serum albumin
Controlled release
Doxorubicin
doxorubicin hydrochloride
drug carrier
Drug delivery
Drugs
Hydrodynamics
Nanocomposites
Nanomaterials
Nanoparticles
Nanospheres
Nanostructure
pH effects
Polymerization
rhodamine
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Summary:New kinds of narrowly distributed protein‐based nanoparticles, bovine serum albumin‐Poly (acrylic acid) (BSA/PAA) nanospheres, and nanocapsules were prepared via in situ polymerization, swelling, and re‐aggregation. The structure and morphology of the nanospheres were characterized by UV‐Vis, FT‐IR, DLS, and TEM. The stability of the BSA/PAA nanospheres and nanocapsules was increased when their skeletons were fixed by cross‐linked agents. The nanospheres carried a positive charge and their size was about 80–110 nm. The protein‐based nanocapsules were stimuli‐responsive with pH value and their hydrodynamic diameter varied from 70 to 230 nm with changes of pH. In vitro release experiments of Rhodamine B and Doxorubicin hydrochloride showed that these biopolymer nanoparticles provided a controlled release of the entrapped drugs for 300 hr. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:1042-7147
1099-1581
1099-1581
DOI:10.1002/pat.1481