Cortical excitability distinguishes ALS from mimic disorders

Highlights ► This study addresses a diagnostic test for amyotrophic lateral sclerosis (ALS), reliably distinguishing ALS from mimic disorders. ► Using it, the diagnosis of ALS can be hastened by approximately 8 months, enabling implementation of specific treatments and recruitment into drug trials....

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Bibliographic Details
Published in:Clinical neurophysiology 2011-09, Vol.122 (9), p.1860-1866
Main Authors: Vucic, Steve, Cheah, Benjamin C, Yiannikas, Con, Kiernan, Matthew C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Algorithms
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - diagnosis
Amyotrophic Lateral Sclerosis - physiopathology
Area Under Curve
Biological and medical sciences
Cerebral Cortex - physiopathology
Cortical excitability
Diagnosis
Diagnosis, Differential
Electrodiagnosis. Electric activity recording
Evoked Potentials, Motor - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Nervous system
Neurology
ROC Curve
Sensitivity and Specificity
Threshold tracking TMS
Transcranial Magnetic Stimulation - methods
Vertebrates: nervous system and sense organs
Young Adult
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Description
Summary:Highlights ► This study addresses a diagnostic test for amyotrophic lateral sclerosis (ALS), reliably distinguishing ALS from mimic disorders. ► Using it, the diagnosis of ALS can be hastened by approximately 8 months, enabling implementation of specific treatments and recruitment into drug trials. ► The study provides insights into mechanisms underlying ALS.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2010.12.062