Biomaterial-Mediated Delivery of Microenvironmental Cues for Repair and Regeneration of Articular Cartilage

Articular cartilage injuries are one of the most challenging problems in musculoskeletal medicine due to the poor intrinsic regenerative capacity of this tissue. The lack of efficient treatment modalities motivates research into tissue engineering: combining cells, biomaterials mimicking extracellul...

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Bibliographic Details
Published in:Molecular pharmaceutics 2011-08, Vol.8 (4), p.994-1001
Main Authors: Toh, Wei Seong, Spector, Myron, Lee, Eng Hin, Cao, Tong
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biomaterials
Cartilage, Articular - cytology
Cartilage, Articular - injuries
Humans
Regenerative Medicine - methods
Tissue Engineering - methods
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Summary:Articular cartilage injuries are one of the most challenging problems in musculoskeletal medicine due to the poor intrinsic regenerative capacity of this tissue. The lack of efficient treatment modalities motivates research into tissue engineering: combining cells, biomaterials mimicking extracellular matrix (scaffolds) and microenvironmental signaling cues. The aim of this review is to focus on the use of biomaterials as delivery systems for microenvironmental cues in relation to their applications for treatment of cartilage defects. The latest advances in cartilage tissue engineering and regeneration are critically reviewed to demonstrate an outline of challenges toward biomaterial-based approaches of cartilage regeneration.
ISSN:1543-8384
1543-8392
DOI:10.1021/mp100437a