In vitro analysis of the anthelmintic activity of forage chicory (Cichorium intybus L.) sesquiterpene lactones against a predominantly Haemonchus contortus egg population

The anthelmintic activity of chicory (Cichorium intybus L.) herbage has been attributed to sesquiterpene lactones. Chicory leaves contain significant amounts of lactucin (LAC), 8-deoxylactucin (DOL), and lactucopicrin (LPIC), but the proportions of these three sesquiterpene lactones vary among forag...

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Bibliographic Details
Published in:Veterinary parasitology 2011-08, Vol.180 (3-4), p.298-306
Main Authors: Foster, Joyce G., Cassida, Kimberly A., Turner, Kenneth E.
Format: Article
Language:English
Subjects:
8-Deoxylactucin
Animals
Anthelmintic
Cichorium intybus - chemistry
Cichorium intybus L
Forage chicory
Haemonchus - drug effects
Haemonchus contortus
Lactones - chemistry
Lactones - pharmacology
Molecular Structure
Ovum - drug effects
Plant Leaves - chemistry
Sesquiterpene lactones
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
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Summary:The anthelmintic activity of chicory (Cichorium intybus L.) herbage has been attributed to sesquiterpene lactones. Chicory leaves contain significant amounts of lactucin (LAC), 8-deoxylactucin (DOL), and lactucopicrin (LPIC), but the proportions of these three sesquiterpene lactones vary among forage chicory cultivars. To determine whether the individual compounds differ in anthelmintic activity, we prepared sesquiterpene lactone-enriched extracts from leaves of two forage chicory cultivars, ‘Grasslands Puna’ (Puna) and ‘Forage Feast’, and tested their effects on the hatching of a predominantly Haemonchus contortus egg population. The dominant constituents in the Puna and Forage Feast extracts were DOL and LAC, respectively; LPIC concentrations in the two extracts were similar. Extracts from both cultivars inhibited egg hatching at all concentrations tested (P
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2011.03.013