Transcript clearance during the maternal-to-zygotic transition

Highlights ► Maternal mRNA degradation is a key event during the maternal-to-zygotic transition. ► Maternal mRNA decay is directed by maternally and/or zygotically encoded machineries. ► RNA-binding proteins are mainly involved in the maternally encoded decay activities. ► Small RNAs are often compo...

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Bibliographic Details
Published in:Current opinion in genetics & development 2011-08, Vol.21 (4), p.431-443
Main Authors: Walser, Claudia B, Lipshitz, Howard D
Format: Article
Language:English
Subjects:
Animals
Gene Expression Regulation, Developmental
Humans
Maternal-Fetal Relations
Medical Education
RNA Processing, Post-Transcriptional - genetics
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Messenger, Stored - genetics
RNA, Messenger, Stored - metabolism
Transcription, Genetic
Zygote - cytology
Zygote - metabolism
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Summary:Highlights ► Maternal mRNA degradation is a key event during the maternal-to-zygotic transition. ► Maternal mRNA decay is directed by maternally and/or zygotically encoded machineries. ► RNA-binding proteins are mainly involved in the maternally encoded decay activities. ► Small RNAs are often components of the zygotically encoded decay activities. ► Temporal and spatial control are crucial components of maternal mRNA decay.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2011.03.003