Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities

This paper reveals, for the first time, the functional properties of propolis from an extreme region of Argentine (El Rincón, Province of Catamarca, Argentina), as well as the isolation and identification of bioactive compounds. The antioxidant activity was determined by the ABTS method and β-carote...

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Bibliographic Details
Published in:Natural product communications 2011-06, Vol.6 (6), p.823-827
Main Authors: Vera, Nancy, Solorzano, Eliana, Ordoñez, Roxana, Maldonado, Luis, Bedascarrasbure, Enrique, Isla, María I.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antioxidants - chemistry
Antioxidants - pharmacology
Argentina
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Sensitivity Tests
Propolis - chemistry
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Summary:This paper reveals, for the first time, the functional properties of propolis from an extreme region of Argentine (El Rincón, Province of Catamarca, Argentina), as well as the isolation and identification of bioactive compounds. The antioxidant activity was determined by the ABTS method and β-carotene bleaching. The antibacterial activity was determined on methicillin resistant Staphylococcus aureus (MRSA) by the microdilution method and bioautographic assays. Twelve compounds were isolated and identified by NMR spectroscopy. The main bioactive compounds were 2′,4′-dihydroxy-3′-methoxychalcone (3), 2′,4′-dihydroxychalcone (9), 2′,4′,4-trihydroxy-6′- methoxychalcone (8), 5-hydroxy-4′,7-dimethoxyflavone (4), 4′,5-dihydroxy-3,7,8-trimethoxyflavone (10) and 7-hydroxy- 5,8-dimethoxyflavone (11). All compounds were active against clinical isolates (MIC50 10 μg/ mL) and displayed antioxidant activity (SC50 values of 20 μg/mL). The MIC and SC50 values of the isolated compounds were lower than those obtained with crude propolis extracts, chloroform sub-extracts and isolated fractions.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1100600618