Implementing Cardiovascular Risk Reduction in Patients with Cardiovascular Disease and Diabetes Mellitus

The role of cardiovascular risk reduction in patients with diabetes mellitus is significant as several factors have been found to promote accelerated atherosclerosis in persons with diabetes including hyperglycemia-induced endothelial dysfunction, impaired fibrinolysis, increased platelet aggregatio...

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Bibliographic Details
Published in:The American journal of cardiology 2011-08, Vol.108 (3), p.42B-51B
Main Authors: Nandish, Shailesh, MD, Wyatt, Jamison, MD, Bailon, Oscar, MD, Smith, Mike, MD, Oliveros, Rene, MD, Chilton, Robert, DO
Format: Article
Language:English
Subjects:
Aspirin - therapeutic use
Atherosclerosis
Atherosclerosis - epidemiology
Atherosclerosis - metabolism
Biomarkers
Biomarkers - analysis
Calcium - analysis
Cardiology
Cardiovascular
Cardiovascular disease
Coronary Vessels - chemistry
Diabetes
Diabetic Angiopathies - diagnosis
Diabetic Angiopathies - epidemiology
Diabetic Angiopathies - metabolism
Diabetic Angiopathies - prevention & control
Disease Progression
Genomics
Humans
Life Style
Metabolomics
Myocardial Infarction - epidemiology
Myocardial Infarction - metabolism
Myocardial Ischemia - therapy
Myocardial Revascularization
Platelet Aggregation Inhibitors - therapeutic use
Risk Assessment
Risk factors
Risk Reduction Behavior
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Summary:The role of cardiovascular risk reduction in patients with diabetes mellitus is significant as several factors have been found to promote accelerated atherosclerosis in persons with diabetes including hyperglycemia-induced endothelial dysfunction, impaired fibrinolysis, increased platelet aggregation, plaque instability, dysfunctional arterial remodeling, and fibrotic and calcified coronary arteries. Recent attention has focused on identifying a cardiovascular biomarker that would propose a better noninvasive way to detect or visualize subclinical cardiovascular disease and prevent cardiovascular events. This article reviews the use of commonly used cardiovascular risk assessment tools and emerging biomarkers including coronary artery calcium scanning, metabolomics, genomics, and the role of optimal revascularization and risk reduction strategies and their impact on reducing risk in patients with cardiovascular disease and diabetes.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2011.03.015