An elevated apolipoprotein B/AI ratio is independently associated with microalbuminuria in male subjects with impaired fasting glucose

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2011-08, Vol.21 (8), p.610-616
• Main Authors: Sung, K.-C, Rhee, E.-J, Kim, H, Park, J.-B, Kim, Y.-K, Woo, S, Wilson, A.M
• Format: Article
• Language: English
• Subjects: Adult; albuminuria; Albuminuria - blood; Albuminuria - complications; Albuminuria - physiopathology; Apolipoprotein A-I - blood; apolipoprotein B; Apolipoprotein B/AI; Apolipoproteins B - blood; Asian Continental Ancestry Group; blood glucose; Blood Glucose - analysis; blood serum; body mass index; Cardiovascular; Cholesterol, HDL - blood; Cholesterol, LDL - blood; coronary artery disease; Creatinine - blood; Diabetes Mellitus; diastolic blood pressure; fasting; glucose; high density lipoprotein cholesterol; Humans; Impaired fasting glucose; Logistic Models; low density lipoprotein; Male; Microalbuminuria; Middle Aged; patients; Prediabetic State; Republic of Korea; risk; triacylglycerols; Triglycerides - blood; urine
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2010.01.001

Abstract Background and aims The ratio of apolipoprotein B/AI (apo B/AI) has been used as a marker to predict the risk of coronary artery disease. Recent studies have suggested an association between apolipoprotein B level and microalbuminuria in diabetic subjects. This study was performed to assess a possible association between the apo B/AI ratio and microalbuminuria in male subjects with impaired fasting glucose (IFG). Methods and results In 1266 patients with fasting serum glucose level in the pre-diabetic range, urine albumin-to-creatinine ratio (UACR, μg mg−1 ) was measured from single morning voided urine. The presence of microalbuminuria was defined as a UACR between 30 and 299 μg mg−1 . Participants were stratified into four groups by apo B/AI quartiles, from the lowest to the highest. Apo B/AI was higher with increasing body mass index, higher serum triglyceride and serum low-density lipoprotein cholesterol, systolic and diastolic blood pressure values, but lower with higher high-density lipoprotein cholesterol concentrations. After adjusting for these and other confounding factors, an increased apo B/AI ratio was independently associated with the presence of microalbuminuria. In receiver operating characteristic (ROC) curve analyses, apo B/AI ratio showed the highest correlation with the presence of microalbuminuria among the variables, although statistically not different. Conclusion These findings indicate that apo B/AI ratio shows significant association with microalbuminuria in Korean male subjects with IFG.