A comparison of multislice computerized tomography, cone-beam computerized tomography, and single photon emission computerized tomography for the assessment of bone invasion by oral malignancies

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2011-09, Vol.112 (3), p.367-374
• Main Authors: Dreiseidler, Timo, MD, DMD, Alarabi, Nuri, Ritter, Lutz, MD, DMD, Rothamel, Daniel, MD, DMD, Scheer, Martin, MD, DMD, Zöller, Joachim E., Professor, Mischkowski, Robert A., PhD, MD, DMD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma - diagnostic imaging; Carcinoma - pathology; Cone-Beam Computed Tomography; Dentistry; Humans; Male; Mandibular Neoplasms - diagnostic imaging; Mandibular Neoplasms - pathology; Maxillary Neoplasms - diagnostic imaging; Maxillary Neoplasms - pathology; Medical sciences; Middle Aged; Mouth Neoplasms - diagnostic imaging; Mouth Neoplasms - pathology; Multidetector Computed Tomography; Neoplasm Invasiveness - diagnostic imaging; Neoplasm Staging - instrumentation; Osteosarcoma - diagnostic imaging; Osteosarcoma - pathology; Otorhinolaryngology. Stomatology; Prospective Studies; Reproducibility of Results; Sensitivity and Specificity; Surgery; Tomography, Emission-Computed - instrumentation; Tomography, Emission-Computed - methods; Tomography, Emission-Computed, Single-Photon
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1016/j.tripleo.2011.04.001

Objective The aim of this study was to compare the performance of cone-beam computerized tomography (CBCT) with multislice CT (MSCT) and single photon emission CT (SPECT) in the detection of bone invasion from oral malignancies. Study design In this prospective investigation, 77 patients with histologically proven malignancy of the oral cavity received MSCT, CBCT, and SPECT imaging of the head presurgically. Radiologic evaluations were compared with histopathologic examinations of the resected tumor specimens. Receiver operating characteristic (ROC) analysis as well as the sensitivity, specificity, and positive and negative predictive values were calculated. Results The sensitivity, specificity, positive predictive value, and negative predictive value for MSCT were 0.8, 1.0, 1.0, and 0.75, respectively; for CBCT 0.92, 0.965, 0.98, and 0.875; and for SPECT 0.91, 0.4, 0.7, and 0.75. ROC analysis showed area under the curve values of 0.894 (95% confidence interval [CI] 0.806-0.982) for MSCT; 0.931 (95% CI 0.835-1.000) for CBCT, and 0.716 (95% CI 0.566-0.866) for SPECT. Conclusion CBCT is accurate in predicting malignancies' bone involvement and can compete with MSCT and SPECT in detecting bone invasion in patients with oral malignancies.