The correlation of plasma Aβ42 levels, depressive symptoms, and cognitive function in the Korean elderly

This study aims to investigate whether plasma amyloid beta 1–42 (Aβ42) levels are associated with depressive symptoms and/or cognitive function in community dwelling elderly. Subjects were 123 participants of a population-based project designed to screen community dwelling elderly older than 65years...

Full description

Saved in:
Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2011-08, Vol.35 (7), p.1603-1606
Main Authors: Moon, Yoo Sun, Kang, Suk Hoon, No, Hyun Jin, Won, Moo Ho, Ki, Son Bong, Lee, Sang Kyu, Kim, Do Hoon
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Amyloid beta-Peptides - blood
Asian Continental Ancestry Group
Biological and medical sciences
Cognition - physiology
Cognitive function
Depression
Depression - blood
Depression - epidemiology
Depression - physiopathology
Depressive symptoms
Female
Humans
Male
Medical sciences
Mood disorders
Neuropharmacology
Pharmacology. Drug treatments
Plasma Aβ42
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aims to investigate whether plasma amyloid beta 1–42 (Aβ42) levels are associated with depressive symptoms and/or cognitive function in community dwelling elderly. Subjects were 123 participants of a population-based project designed to screen community dwelling elderly older than 65years old in Gangwon Province, Korea, for the early detection of depression and dementia. Symptoms of depression were assessed using the SGDS-K (Short Geriatric Depression Scale-Korean version), and the MMSE-KC (Mini-Mental State Examination-Korean version) was used to assess cognitive function. Plasma Aβ42 levels were measured with the human amyloid beta ELISA Kit. The elderly with depressive symptoms (SGDS-K score≥8) had higher plasma Aβ42 levels than those without depressive symptoms (SGDS-K score
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2011.05.013