Effect of Preliminary Load of Macrophages with Silicium Dioxide on Phagocytosis of BCG Strain Micobacteria by Macrophages and Antimicrobial Activity

We studied the effect of preliminary loading of peritoneal macrophages with silicium dioxide on in vitro viability, phagocytosis of BCG strain mycobacteria, and the capability to destroy the phagocytosed mycobacterium tuberculosis. It was shown that preliminary loading of macrophages with silicium d...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2010-10, Vol.149 (4), p.534-536
Main Authors: Arkhipov, S. A, Shkurupy, V. A, Bugrimova, Yu. S
Format: Article
Language:English
Subjects:
Animals
Antibacterial activity
BCG mycobacteria
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cells, Cultured
Internal Medicine
Laboratory Medicine
Macrophages
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - immunology
Male
Mice
Mycobacterium bovis - immunology
Mycobacterium tuberculosis
Pathology
Phagocytosis - immunology
silicium dioxide
Silicon Dioxide - pharmacology
Silicotuberculosis - immunology
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Summary:We studied the effect of preliminary loading of peritoneal macrophages with silicium dioxide on in vitro viability, phagocytosis of BCG strain mycobacteria, and the capability to destroy the phagocytosed mycobacterium tuberculosis. It was shown that preliminary loading of macrophages with silicium dioxide did not reduce their viability and stimulated phagocytosis of BCG strain mycobacteria, but reduced their antibacterial activity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0986-0