Endogenous antioxidants and Nasal human epithelium response to air pollutants: genotoxic and inmmunocytochemical evaluation

Nasal epithelium is a source for identifying atmospheric pollution impact. Antioxidants play a relevant role in the protection of the cells from environmental injury, but scarce information is available about the interaction of endogenous antioxidants and genotoxic damage in nasal epithelium from ur...

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Bibliographic Details
Published in:Journal of applied toxicology 2010-10, Vol.30 (7), p.661-665
Main Authors: Fortoul, T. I., Rojas-Lemus, M., Avila-Casado, M. C., Rodriguez-Lara, V., Montaño, L. F., Muñoz-Comonfort, A., Lopez-Zepeda, L. S.
Format: Article
Language:English
Subjects:
Air
Air pollution
Antioxidants
atmospheric pollution
Autumn
Biological and medical sciences
catalase
Damage
endogenous antioxidants
Environmental pollutants toxicology
Epithelium
Genotoxicity
immunocytochemistry
Medical sciences
nasal epithelium
Pollutants
Populations
SCGE
Superoxide dismutase
Toxicology
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Summary:Nasal epithelium is a source for identifying atmospheric pollution impact. Antioxidants play a relevant role in the protection of the cells from environmental injury, but scarce information is available about the interaction of endogenous antioxidants and genotoxic damage in nasal epithelium from urban populations highly exposed to traffic‐generated air pollutants. An immunocytochemical and genotoxic evaluation was implemented in nasal cell epithelium in a population chronically exposed to atmospheric pollution from autumn 2004 to autumn 2005. Superoxide dismutase (SOD) and Catalase (CAT) were evaluated in nasal scrapings by morphometry and genotoxicity by comet assay. An increase in DNA damage correlates with a decrease in SOD and CAT in nasal cells during autumn and the inverse result was observed during summer (R = 0.88). Not only should exogenous antioxidant supplements be encouraged, but also a healthy diet to strengthen intracellular defenses against oxidative stress induced by exposure to air pollutants. Nasal epithelium is a source for identifying air pollution impact. In our report we evaluated a population chronically exposed to atmospheric pollutants and correlated the DNA damage and the presence of endogenous antioxidants. We observed an increase in DNA damage when endogenous antioxidants decreased. Our conclusion is to strengthen a healthy diet with exogenous antioxidants to decrease the health impact of atmospheric pollutants.
ISSN:0260-437X
1099-1263
1099-1263
DOI:10.1002/jat.1538