Effect of lidocaine on ovalbumin and egg albumin foam stability

Foam fractionation is a simple separation process that can remove and concentrate hydrophobic molecules such as proteins, surfactants, and organic wastes from an aqueous solution. Bovine serum albumin and ovalbumin have been widely used as model proteins due to their strong foaming potential and low...

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Bibliographic Details
Published in:Applied biochemistry and biotechnology 2003, Vol.105 -108 (1-3), p.905-911
Main Authors: Burapatana, Vorakan, Butler, Ernest E, Chauhan, Gaurav, Hartig, Sean, Kincaid, Helen, Wang, Tong, Samsudin, Shayrizal, Tanner, Robert D
Format: Article
Language:English
Subjects:
Antifoaming Agents - chemistry
Antifoaming Agents - isolation & purification
Aqueous solutions
Bovine serum albumin
Decay rate
Drug Stability
Egg Proteins - chemistry
Egg Proteins - drug effects
Egg Proteins - isolation & purification
Foam separation
Foaming
Fractionation
Hydrophobicity
Lidocaine
Lidocaine - pharmacology
Organic wastes
Ovalbumin
Ovalbumin - chemistry
Ovalbumin - drug effects
Ovalbumin - isolation & purification
Proteins
Serum albumin
Stability analysis
Surface Tension
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Summary:Foam fractionation is a simple separation process that can remove and concentrate hydrophobic molecules such as proteins, surfactants, and organic wastes from an aqueous solution. Bovine serum albumin and ovalbumin have been widely used as model proteins due to their strong foaming potential and low price. Here, we study the effect of lidocaine on albumin foam, since drugs like lidocaine are known to bind with albumin. We observed that lidocaine not only enhances the amount of foam produced but also the stability of that foam as well. The foam stability was evaluated as the decay rate constant of the foam, determined from a change in height (or volume) of the foam over a given time period.
ISSN:0273-2289
0273-2289
1559-0291
DOI:10.1385/ABAB:108:1-3:905