Relative renal function with MAG-3 and DMSA in children with unilateral hydronephrosis

Aim Tc-99m DMSA renal cortical scan is a reference method for determining relative renal function (RRF). Tc-99m MAG-3 is also recommended for the estimation of RRF, particularly in young children. The aims of this study were to compare MAG-3 and DMSA RRF estimations and to assess the reproducibility...

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Bibliographic Details
Published in:Annals of nuclear medicine 2010-11, Vol.24 (9), p.691-695
Main Authors: Aktaş, Gül Ege, Inanir, Sabahat
Format: Article
Language:English
Subjects:
Antigens, Dermatophagoides
Antigens, Plant
Arthropod Proteins
Child
Child, Preschool
Female
Humans
Hydronephrosis - diagnosis
Hydronephrosis - diagnostic imaging
Hydronephrosis - physiopathology
Imaging
Infant
Infant, Newborn
Kidney - diagnostic imaging
Kidney - physiopathology
Male
Medicine
Medicine & Public Health
Nuclear Medicine
Radiology
Radionuclide Imaging
Reproducibility of Results
Retrospective Studies
Short Communication
Technetium Tc 99m Dimercaptosuccinic Acid
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Summary:Aim Tc-99m DMSA renal cortical scan is a reference method for determining relative renal function (RRF). Tc-99m MAG-3 is also recommended for the estimation of RRF, particularly in young children. The aims of this study were to compare MAG-3 and DMSA RRF estimations and to assess the reproducibility of these estimations in children with unilateral hydronephrosis. Methods We reviewed MAG-3 and DMSA scans of 19 children with unilateral hydronephrosis and a normal contralateral unit. All were imaged with 2 agents within 3 months. MAG-3 RRF was calculated using 2 different time intervals (1–2 and 2–3 min) and perirenal C-type region of background activity. No background correction method was used in the calculation of DMSA RRF. All data were processed twice by two independent operators. Results In the repeated estimates of MAG-3 RRF, the maximum mean intra-observer and inter-observer differences were 0.9% (SD 1.7%) and 1.4% (SD 3.3%), respectively. Intra-method analysis showed statistically significant agreement between repeated measures of RRF for two agents as well as for two operators (intra-class cross-correlation coefficients of early and later phase of MAG-3 and DMSA RRF values were 0.979, 0.993 and 0.996 for operator 1, and 0.986, 0.973 and 0.995 for operator 2, respectively; p  
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-010-0397-3