Local secretion/shedding of tumor-derived CD83 molecules as a novel tumor escape mechanism

CD83, a characteristic marker of activated dendritic cells, is also expressed by tumor cell lines from various origins and by primary lung cancers. Here, we show that CD83+ tumor cells (from a primary lung cancer and from an established breast cancer cell line) release in their culture supernatants...

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Bibliographic Details
Published in:Molecular immunology 2008-07, Vol.45 (12), p.3502-3504
Main Authors: Baleeiro, R.B., Barbuto, J.A.M.
Format: Article
Language:English
Subjects:
Antigens, CD - immunology
Antigens, Neoplasm - immunology
CD83
CD83 Antigen
Cell Proliferation
Dendritic cells
Humans
Immunoglobulins - immunology
Immunosuppression
Lymphocyte Activation
Membrane Glycoproteins - immunology
T-Lymphocytes - cytology
Tumor Cells, Cultured
Tumor Escape - immunology
Tumor escape mechanisms
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Summary:CD83, a characteristic marker of activated dendritic cells, is also expressed by tumor cell lines from various origins and by primary lung cancers. Here, we show that CD83+ tumor cells (from a primary lung cancer and from an established breast cancer cell line) release in their culture supernatants a soluble factor that is able to block, in a dose-dependent manner, CD4+ and CD8+ T cell proliferative responses to allogeneic dendritic cells. This factor was removed from the medium by incubation in anti-CD83 covered plates, indicating that it could be one of the known soluble forms of the CD83 molecule, released in the medium by the cultured tumor cells. This phenomenon, happening in vivo, in the tumor microenvironment, could affect profoundly anti-tumor immune responses and should, therefore, be considered in immunotherapeutic approaches to cancer.
ISSN:0161-5890
1872-9142
DOI:10.1016/j.molimm.2008.04.005