Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

• Published in: Bioorganic & medicinal chemistry 2008-11, Vol.16 (21), p.9588-9595
• Main Authors: Brito, Adriana S., Arimatéia, Dayse S., Souza, Lucilla R., Lima, Marcelo A., Santos, Vanessa O., Medeiros, Valquíria P., Ferreira, Paula A., Silva, Rodrigo A., Ferreira, Carmen V., Justo, Giselle Z., Leite, Edda L., Andrade, Giulianna P.V., Oliveira, Fernanda W., Nader, Helena B., Chavante, Suely F.
• Format: Article
• Language: English
• Subjects: Animals; Anti-inflammatory activity; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anticoagulant activity; Anticoagulants - chemistry; Anticoagulants - pharmacology; Biological and medical sciences; Crustacean heparin-like compound; Decapoda; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Fish and seafood industries; Food industries; Fundamental and applied biological sciences. Psychology; General pharmacology; Glycosaminoglycans; Glycosaminoglycans - chemistry; Glycosaminoglycans - isolation & purification; Glycosaminoglycans - pharmacology; Hemorrhage - drug therapy; Hemorrhagic activity; Heparin; Heparin - chemistry; Heparin - isolation & purification; Heparin - pharmacology; Heparitin Sulfate - metabolism; Inflammation - drug therapy; Invertebrate; Leukocytes - drug effects; Leukocytes - enzymology; Litopenaeus vannamei; Marine; Matrix Metalloproteinase 9 - metabolism; Matrix metalloproteinases; Medical sciences; Neutrophils - drug effects; Penaeidae - physiology; Peritoneal Cavity - physiology; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Rabbits; Rats; Swine
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2008.09.020

The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly ( p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug.