The role of IgG antibodies in allergy and immunotherapy

To cite this article: Aalberse R. The role of IgG antibodies in allergy and immunotherapy. Allergy 2011; 66 (Suppl. 95): 28–30. In specific immunotherapy (SIT), a beneficial response is associated with an increase in allergen‐specific IgG4. This does not indicate that IgE‐producing B cells have swit...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2011-07, Vol.66 (s95), p.28-30
Main Author: Aalberse, R.
Format: Article
Language:English
Subjects:
Allergen specific IgG4
Allergens - immunology
Allergies
antibody class switching
B-Lymphocytes - immunology
Biological and medical sciences
Bispecific antibodies
Dermatology
DNA
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Hypersensitivity
Hypersensitivity - immunology
Hypersensitivity - therapy
Immunoglobulin E
Immunoglobulin E - immunology
Immunoglobulin G
Immunoglobulin G - immunology
Immunoglobulins
immunological memory
Immunotherapy
Interleukin 10
Lymphocytes B
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
specific immunotherapy
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Summary:To cite this article: Aalberse R. The role of IgG antibodies in allergy and immunotherapy. Allergy 2011; 66 (Suppl. 95): 28–30. In specific immunotherapy (SIT), a beneficial response is associated with an increase in allergen‐specific IgG4. This does not indicate that IgE‐producing B cells have switched to IgG4 production, because in human DNA, IgE is downstream from IgG4. Thus, by conventional switching, B cells should produce IgG4 before IgE. This presentation discusses three possible hypotheses explaining the favourable association between IgG4 and SIT, including that SIT causes B cells to become regulatory. Regulatory B cells may produce cytokines like IL‐10 that promote IgG4 production. IgG4 can undergo in vitro switching to create bispecific antibodies that recognize more than one antigen, which has important consequences for reducing IgE–allergen complexes in immunotherapy.
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.2011.02628.x