A unique case of IgD-only splenic marginal-zone lymphoma with mutated immunoglobulin genes: Ontogenetic implications

Abstract Splenic marginal zone lymphoma (SMZL) is a rare indolent lymphoma subtype which accounts for less than 1% of all non-Hodgkin's lymphomas. We here report a unique case of IgD-only SMZL with mutated immunoglobulin variable region genes and discuss possible ontogenetic derivation.

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Bibliographic Details
Published in:Leukemia research 2008-01, Vol.32 (1), p.155-157
Main Authors: Papadaki, Theodora, Stamatopoulos, Kostas, Mavrommatis, Theodore, Anagnostopoulos, Achilles, Anagnostou, Dimitra
Format: Article
Language:English
Subjects:
Aged
Female
Genes, Immunoglobulin
Hematology, Oncology and Palliative Medicine
Humans
IgD
Immunoglobulin D - metabolism
Immunoglobulin genes
Immunoglobulin Variable Region - genetics
Immunoglobulins
Immunohistochemistry
Lymphoma
Lymphoma, B-Cell, Marginal Zone
Marginal-zone
Mutation
Non-Hodgkin's lymphoma
Ontogeny
Somatic hypermutation
Spleen
Splenic Neoplasms - genetics
Variable region
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Description
Summary:Abstract Splenic marginal zone lymphoma (SMZL) is a rare indolent lymphoma subtype which accounts for less than 1% of all non-Hodgkin's lymphomas. We here report a unique case of IgD-only SMZL with mutated immunoglobulin variable region genes and discuss possible ontogenetic derivation.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2007.03.013