Organic extracts of urban air pollution particulate matter (PM2.5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells (BEAS-2B cells)

• Published in: Mutation research. Genetic toxicology and environmental mutagenesis 2011-08, Vol.723 (2), p.142-151
• Main Authors: Oh, Seung Min, Kim, Ha Ryong, Park, Yong Joo, Lee, Soo Yeun, Chung, Kyu Hyuck
• Format: Article
• Language: English
• Subjects: Air pollution; Airborne particulates; Aromatics; Atmospheric pollution; Atmospheric pollution and health; Atmospheric pollution by motor vehicles; Atmospheric pollution models; Bioassay-directed fractionation; Cancer; Catalase; CBMN assay; Cells; Chlorinated hydrocarbons; Comet assay; DNA; DNA damage; Endonuclease; Epithelial cells; Genotoxicity; Inhalation; ketones; Lung cancer; Lungs; Mannitol; Mortality; Mutagenesis; Oxidative stress; Particle size; Particulate atmospheric pollution; Particulate matter; Particulate matter in atmosphere; Particulate matter in urban air; Particulates; PM2.5; Pollutants; Quinone; Reactive oxygen species; Sodium selenite; Superoxide dismutase; Toxicity; Traffic; Urban areas; Urban atmospheric pollution
• ISSN: 1383-5718; 1879-3592
• DOI: 10.1016/j.mrgentox.2011.04.003

Traffic is a major source of particulate matter (PM), and ultrafine particulates and traffic intensity probably contribute significantly to PM-related health effects. As a strong relationship between air pollution and motor vehicle-originated pollutants has been shown to exist, air pollution genotoxicity studies of urban cities are steadily increasing. In Korea, the death rate caused by lung cancer is the most rapidly increased cancer death rate in the past 10 years. In this study, genotoxicity of PM2.5 (