Thyroid hormone deficiency disrupts rat eye neurodevelopment

Abstract Clinical and experimental studies have highlighted the role played by thyroid hormones (TH) in neural and neuro-sensorial development. However, knowledge on TH mechanisms on the developing visual system is still incomplete. To uncover TH actions on the eyes and vision we carried out a micro...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2011-05, Vol.1392, p.16-26
Main Authors: Pinazo-Durán, Maria D, Pons-Vázquez, Sheila, Gallego-Pinazo, Roberto, Galbis Estrada, Carmen, Zanón-Moreno, Vicente, Vila Bou, Vicente, Sanz Solana, Pedro
Format: Article
Language:English
Subjects:
Age Factors
animal models
Animals
Animals, Newborn
Biological and medical sciences
brain
Development
Disease Models, Animal
Embryo, Mammalian
Eye and associated structures. Visual pathways and centers. Vision
Female
Fundamental and applied biological sciences. Psychology
Hormone therapy
Hypothyroidism - chemically induced
Hypothyroidism - pathology
Imidazoles - toxicity
Male
Microscopy, Electron, Transmission - methods
morphometry
myelination
nerve tissue
neurodevelopment
Neurology
Optic nerve
Optic Nerve - growth & development
Optic Nerve - pathology
Optic Nerve - ultrastructure
Organ Size
Pregnancy
Rats
Rats, Wistar
Retina
Retina - embryology
Retina - growth & development
Retina - pathology
Retina - ultrastructure
therapeutics
Thyroid hormone
thyroid hormones
Thyroid Hormones - deficiency
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Clinical and experimental studies have highlighted the role played by thyroid hormones (TH) in neural and neuro-sensorial development. However, knowledge on TH mechanisms on the developing visual system is still incomplete. To uncover TH actions on the eyes and vision we carried out a microscopical study on the role of TH in the developing retina and optic nerve, in a rat model of controlled TH deficiency (THD). Morphometric and stereological analyses of the retina and optic nerve showed a reduction in the volume of the eye (p < 0.001) and optic nerve cross-sectional area (p < 0.001), and thinning of the retinal layers (p < 0.001). Glial development and myelination was significantly delayed in the THD optic nerves (p < 0.001), as compared to controls. The data indicate that TH play an essential role in neuro-retinogenesis. Substitutive TH therapy in critical periods, should be considered in hypothyroidism-related eye disorders as well as neurodegenerative retinal processes.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2011.04.005