Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A sub(3 adenosine receptor antagonists)

We recently described the synthesis of 1-benzyl-3-propyl-1H,8H-imidazo[2,1-f]purine-2,4-diones, new potent and selective A sub(3 adenosine receptor antagonists containing a xanthine core. The present work can be considered an extension of our SAR studies on related structures in which the effect of...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2008-12, Vol.16 (24), p.10281-10294
Main Authors: Baraldi, Pier Giovanni, Preti, Delia, Tabrizi, Mojgan Aghazadeh, Romagnoli, Romeo, Saponaro, Giulia, Baraldi, Stefania, Botta, Maurizio, Bernardini, Cesare, Tafi, Andrea, Tuccinardi, Tiziano, Martinelli, Adriano, Varani, Katia, Borea, Pier Andrea
Format: Article
Language:English
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Summary:We recently described the synthesis of 1-benzyl-3-propyl-1H,8H-imidazo[2,1-f]purine-2,4-diones, new potent and selective A sub(3 adenosine receptor antagonists containing a xanthine core. The present work can be considered an extension of our SAR studies on related structures in which the effect of different kind of substitutions at the 1-, 3- and 8-positions has been evaluated in order to improve both the potency and the hydrophilicity of the originally synthesised molecules. The A) sub(3) binding disposition of these compounds was also investigated through docking and 3D-QSAR studies.
ISSN:0968-0896
DOI:10.1016/j.bmc.2008.10.049