Multifunctional implant surfaces: Surface characterization and bone response to acid-etched Ti implants surface-modified by fibrillar collagen I

The goal of the study was the evaluation of the effect of biochemical surface modification by collagen on the bone response to acid‐etched titanium surfaces. Fibrillar type I porcine collagen was adsorbed and covalently linked to acid‐etched Ti disks and implants. Adhesion, growth, and specific alka...

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Published in:Journal of biomedical materials research. Part A 2010-07, Vol.94A (1), p.271-279
Main Authors: Morra, M., Cassinelli, C., Cascardo, G., Bollati, D., Rodriguez y Baena, R.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Line
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - metabolism
collagen
Collagen Type I - chemistry
Collagen Type I - metabolism
dental implants
Fibrillar Collagens - chemistry
Fibrillar Collagens - metabolism
Humans
Implants, Experimental
Male
Materials Testing
Medical sciences
Osteoblasts - cytology
Osteoblasts - physiology
Rabbits
surface analysis
surface modification
Surface Properties
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Swine
Technology. Biomaterials. Equipments
Titanium
titanium surfaces
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Summary:The goal of the study was the evaluation of the effect of biochemical surface modification by collagen on the bone response to acid‐etched titanium surfaces. Fibrillar type I porcine collagen was adsorbed and covalently linked to acid‐etched Ti disks and implants. Adhesion, growth, and specific alkaline phosphatase (ALP) activity of osteoblast‐like SaOS2 cells were evaluated. Implants in the femur and tibia of rabbit were performed for 2 and 4 weeks and relevant bone to implant contact (BIC) was evaluated by histomorphometry. Results show that cell morphology and growth are controlled by the rough acid‐etched implants topography. Specific metabolic activity (ALP) is significantly increased by the collagen overlayer. Importantly, surface modification by collagen increases the speed of periimplant bone formation, resulting in significantly higher BIC both in femur and tibia at 2 weeks. These results suggest that morphological (surface topography) and biochemical (surface linking of bioactive molecules) cues can cooperate and yield multifunctional implant surfaces. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
ISSN:1549-3296
1552-4965
1552-4965
DOI:10.1002/jbm.a.32702