Comparative study of tumor hypoxia by diffuse optical spectroscopy and immunohistochemistry in two tumor models

The capabilities of diffuse optical spectroscopy for noninvasive assessing of oxygen status in experimental tumors have been demonstrated. Specific features of the distribution of total hemoglobin, oxygenated hemoglobin, deoxygenated hemoglobin, and blood‐oxygen saturation were shown on two tumor mo...

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Bibliographic Details
Published in:Journal of biophotonics 2010-12, Vol.3 (12), p.743-751
Main Authors: Maslennikova, Anna V., Orlova, Anna G., Golubiatnikov, German Yu, Kamensky, Vladislav A., Shakhova, Natalia M., Babaev, Aleksey A., Snopova, Ludmila B., Ivanova, Irina P., Plekhanov, Vladimir I., Prianikova, Tatyana I., Turchin, Ilya V.
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - analysis
Biomarkers, Tumor - metabolism
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
diffuse optical spectroscopy
Diffusion
Disease Models, Animal
experimental tumors
Female
Hemoglobins - metabolism
hypoxia
Hypoxia - metabolism
Hypoxia - pathology
Immunohistochemistry - methods
Lymph Nodes - metabolism
Lymph Nodes - pathology
Male
Medical Oncology - methods
Nitroimidazoles
noninvasive diagnostics
Optical Devices
Oxygen - metabolism
Radiation-Sensitizing Agents
Rats
Spectrum Analysis - instrumentation
Spectrum Analysis - methods
tumor oxygen status
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Summary:The capabilities of diffuse optical spectroscopy for noninvasive assessing of oxygen status in experimental tumors have been demonstrated. Specific features of the distribution of total hemoglobin, oxygenated hemoglobin, deoxygenated hemoglobin, and blood‐oxygen saturation were shown on two tumor models having different histological structure and functional characteristics. The results obtained by the optical technique were verified by immunohistochemical study of tissue samples marked with exogenous marker of hypoxia – pimonidazole. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
ISSN:1864-063X
1864-0648
1864-0648
DOI:10.1002/jbio.201000060