Cytological analysis of the epithelial cells in patients with oral candidiasis

Summary The aim of this study was to evaluate oral epithelial cells of the oral mucosa infected by Candida albicans using exfoliative cytology. Oral smears were collected from clinically normal‐appearing mucosa by liquid‐based exfoliative cytology of 60 individuals (30 patients with oral candidiasis...

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Bibliographic Details
Published in:Mycoses 2011-07, Vol.54 (4), p.e130-e135
Main Authors: Loss, Rafael, Sandrin, Rodrigo, França, Beatriz Helena Sottile, de Azevedo-Alanis, Luciana Reis, Grégio, Ana Maria Trindade, Machado, Maria Ângela Naval, Lima, Antonio Adilson Soares de
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Candida
Candida albicans
Candida spp
Candidiasis
Candidiasis, Oral - pathology
candidosis
Denture stomatitis
Epithelial cells
Epithelial Cells - cytology
Female
Humans
Infection
Male
Middle Aged
Mouth Mucosa - pathology
Mucosa
Organelles - ultrastructure
Vacuoles
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Summary:Summary The aim of this study was to evaluate oral epithelial cells of the oral mucosa infected by Candida albicans using exfoliative cytology. Oral smears were collected from clinically normal‐appearing mucosa by liquid‐based exfoliative cytology of 60 individuals (30 patients with oral candidiasis and 30 healthy controls matched for age and gender) and analysed for morphologic and cytomorphometric technique. Morphologically, candida‐infected epithelial cells exhibited nuclear enlargement, perinuclear rings, discrete orangeophilia, and cytoplasmic vacuoles. The cytomorphometric analysis demonstrated that the cytoplasmic area (CA) of the epithelial cells was diminished in patients undergoing candidiasis as compared to the non‐infected controls. In addition, there was an augmentation in nuclear area (NA) and NA/CA area ratio. This study revealed that oral mucosa of patients undergoing candidal infection exhibited significant changes in the size and shape of the oral epithelial cells.
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2009.01857.x