In vitro substance P-dependent induction of bone marrow cells in common (CD10) acute lymphoblastic leukaemia

Abstract The aim of the present research was to investigate the possible in vitro stimulatory effect of substance P (SP) on blasts induction in childhood common acute lymphoblastic leukaemia (ALL). Bone marrow aspirates were incubated with SP receptor agonist or antagonist (spantide) and subsequentl...

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Bibliographic Details
Published in:Leukemia research 2008-01, Vol.32 (1), p.97-102
Main Authors: Nowicki, M, Ostalska-Nowicka, D, Miskowiak, B
Format: Article
Language:English
Subjects:
Adolescent
Bone Marrow Cells
Cell Proliferation
Child
Child, Preschool
Children
Female
Hematology, Oncology and Palliative Medicine
Humans
Interleukin-1b
Interleukin-1beta - metabolism
Leukaemia
Male
Neurokinin-1 Receptor Antagonists
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Substance P
Substance P - analogs & derivatives
Substance P - pharmacology
Substance P - physiology
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Summary:Abstract The aim of the present research was to investigate the possible in vitro stimulatory effect of substance P (SP) on blasts induction in childhood common acute lymphoblastic leukaemia (ALL). Bone marrow aspirates were incubated with SP receptor agonist or antagonist (spantide) and subsequently assayed for the presence of human interleukin (IL)-1b using ELISA kit. Blast cells incubated with SP receptor agonist were found to result in a significant increase of IL-1b concentration while incubated with spantide resulted in control levels of IL-1b. These findings suggest the novel possible role of SP in blasts proliferation in childhood ALL of common (CD10) origin.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2007.05.006