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Preferential patterns of myocardial iron overload by multislice multiecho T2 CMR in thalassemia major patients
T*2 multislice multiecho cardiac MR allows quantification of the segmental distribution of myocardial iron overload. This study aimed to determine if there were preferential patterns of myocardial iron overload in thalassemia major. Five hundred twenty‐three thalassemia major patients underwent card...
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| Published in: | Magnetic resonance in medicine 2010-07, Vol.64 (1), p.211-219 |
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| container_title | Magnetic resonance in medicine |
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| creator | Meloni, Antonella Positano, Vincenzo Pepe, Alessia Rossi, Giuseppe Dell'Amico, MariaChiara Salvatori, Cristina Keilberg, Petra Filosa, Aldo Sallustio, Giuseppina Midiri, Massimo D'Ascola, Domenico Santarelli, Maria Filomena Lombardi, Massimo |
| description | T*2 multislice multiecho cardiac MR allows quantification of the segmental distribution of myocardial iron overload. This study aimed to determine if there were preferential patterns of myocardial iron overload in thalassemia major. Five hundred twenty‐three thalassemia major patients underwent cardiac MR. Three short‐axis views of the left ventricle were acquired and analyzed using a 16‐segment standardized model. The T*2 value on each segment was calculated, as well as the global value. Four main circumferential regions (anterior, septal, inferior, and lateral) were defined. Significant segmental variability was found in the 229 patients with significant myocardial iron overload (global T*2 |
| doi_str_mv | 10.1002/mrm.22410 |
| format | article |
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This study aimed to determine if there were preferential patterns of myocardial iron overload in thalassemia major. Five hundred twenty‐three thalassemia major patients underwent cardiac MR. Three short‐axis views of the left ventricle were acquired and analyzed using a 16‐segment standardized model. The T*2 value on each segment was calculated, as well as the global value. Four main circumferential regions (anterior, septal, inferior, and lateral) were defined. Significant segmental variability was found in the 229 patients with significant myocardial iron overload (global T*2 <26 ms), subsequently divided into two groups: severe (global T*2 <10 ms) and mild to moderate (global T*2 between 10 and 26 ms) myocardial iron overload. A preferential pattern of iron store in anterior and inferior regions was detected in both groups. This pattern was preserved among the slices. The pattern could not be explained by additive susceptibility artifacts, negligible in heavily iron‐loaded patients. A significantly higher T*2 value in the basal slice was found in patients with severe iron overload. In conclusion, a segmental T*2 cardiac MR approach could identify early iron deposit, useful for tailoring chelation therapy and preventing myocardial dysfunction in the clinical setting. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>ISSN: 1522-2594</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.22410</identifier><identifier>PMID: 20572148</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; beta-Thalassemia - pathology ; cardiovascular magnetic resonance ; Child ; Female ; Heart - diagnostic imaging ; Humans ; Iron Overload - diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Middle Aged ; multislice multiecho T2 ; myocardial iron overload ; Myocardium - pathology ; preferential pattern ; Radiography ; Retrospective Studies ; thalassemia major</subject><ispartof>Magnetic resonance in medicine, 2010-07, Vol.64 (1), p.211-219</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>(c) 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20572148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meloni, Antonella</creatorcontrib><creatorcontrib>Positano, Vincenzo</creatorcontrib><creatorcontrib>Pepe, Alessia</creatorcontrib><creatorcontrib>Rossi, Giuseppe</creatorcontrib><creatorcontrib>Dell'Amico, MariaChiara</creatorcontrib><creatorcontrib>Salvatori, Cristina</creatorcontrib><creatorcontrib>Keilberg, Petra</creatorcontrib><creatorcontrib>Filosa, Aldo</creatorcontrib><creatorcontrib>Sallustio, Giuseppina</creatorcontrib><creatorcontrib>Midiri, Massimo</creatorcontrib><creatorcontrib>D'Ascola, Domenico</creatorcontrib><creatorcontrib>Santarelli, Maria Filomena</creatorcontrib><creatorcontrib>Lombardi, Massimo</creatorcontrib><title>Preferential patterns of myocardial iron overload by multislice multiecho T2 CMR in thalassemia major patients</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>T*2 multislice multiecho cardiac MR allows quantification of the segmental distribution of myocardial iron overload. This study aimed to determine if there were preferential patterns of myocardial iron overload in thalassemia major. Five hundred twenty‐three thalassemia major patients underwent cardiac MR. Three short‐axis views of the left ventricle were acquired and analyzed using a 16‐segment standardized model. The T*2 value on each segment was calculated, as well as the global value. Four main circumferential regions (anterior, septal, inferior, and lateral) were defined. Significant segmental variability was found in the 229 patients with significant myocardial iron overload (global T*2 <26 ms), subsequently divided into two groups: severe (global T*2 <10 ms) and mild to moderate (global T*2 between 10 and 26 ms) myocardial iron overload. A preferential pattern of iron store in anterior and inferior regions was detected in both groups. This pattern was preserved among the slices. The pattern could not be explained by additive susceptibility artifacts, negligible in heavily iron‐loaded patients. A significantly higher T*2 value in the basal slice was found in patients with severe iron overload. In conclusion, a segmental T*2 cardiac MR approach could identify early iron deposit, useful for tailoring chelation therapy and preventing myocardial dysfunction in the clinical setting. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>beta-Thalassemia - pathology</subject><subject>cardiovascular magnetic resonance</subject><subject>Child</subject><subject>Female</subject><subject>Heart - diagnostic imaging</subject><subject>Humans</subject><subject>Iron Overload - diagnostic imaging</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multislice multiecho T2</subject><subject>myocardial iron overload</subject><subject>Myocardium - pathology</subject><subject>preferential pattern</subject><subject>Radiography</subject><subject>Retrospective Studies</subject><subject>thalassemia major</subject><issn>0740-3194</issn><issn>1522-2594</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkU9PGzEQxa2qqKTQQ79A5VtPG_w33j2iFQSkpEUIxNHyemcVU3sd7A2Qb88mAa49zdPM781I8xD6ScmUEsLOQgpTxgQlX9CESsYKJivxFU2IEqTgtBLH6HvOj4SQqlLiGzpmRCpGRTlB_U2CDhL0gzMer80wQOozjh0O22hNandtl2KP4zMkH02Lmy0OGz-47J2FgwS7iviO4Xp5i12Ph5XxJmcIzuBgHmPaLXbjjXyKjjrjM_x4ryfo_vLirr4qFn_n1_X5onBMEVKAkE3bgqENpzMrleg6oEKJSkoueUOtsd2sUWMPBJWlEpbOBFAlrWqpkIKfoN-HvesUnzaQBx1ctuC96SFusi5LTljJ-P9JxblQinI1kr_eyU0ToNXr5IJJW_3xzBE4OwAvzsP2c06J3qWkx5T0PiW9vF3uxegoDg6XB3j9dJj0T88UV1I__JlrcsPquawv9RV_A2XXk64</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Meloni, Antonella</creator><creator>Positano, Vincenzo</creator><creator>Pepe, Alessia</creator><creator>Rossi, Giuseppe</creator><creator>Dell'Amico, MariaChiara</creator><creator>Salvatori, Cristina</creator><creator>Keilberg, Petra</creator><creator>Filosa, Aldo</creator><creator>Sallustio, Giuseppina</creator><creator>Midiri, Massimo</creator><creator>D'Ascola, Domenico</creator><creator>Santarelli, Maria Filomena</creator><creator>Lombardi, Massimo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201007</creationdate><title>Preferential patterns of myocardial iron overload by multislice multiecho T2 CMR in thalassemia major patients</title><author>Meloni, Antonella ; Positano, Vincenzo ; Pepe, Alessia ; Rossi, Giuseppe ; Dell'Amico, MariaChiara ; Salvatori, Cristina ; Keilberg, Petra ; Filosa, Aldo ; Sallustio, Giuseppina ; Midiri, Massimo ; D'Ascola, Domenico ; Santarelli, Maria Filomena ; Lombardi, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2700-e45bddea1b316c574ffe1474955353b1cacf6b7e14e415874c164e175c7d14543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>beta-Thalassemia - pathology</topic><topic>cardiovascular magnetic resonance</topic><topic>Child</topic><topic>Female</topic><topic>Heart - diagnostic imaging</topic><topic>Humans</topic><topic>Iron Overload - diagnostic imaging</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multislice multiecho T2</topic><topic>myocardial iron overload</topic><topic>Myocardium - pathology</topic><topic>preferential pattern</topic><topic>Radiography</topic><topic>Retrospective Studies</topic><topic>thalassemia major</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meloni, Antonella</creatorcontrib><creatorcontrib>Positano, Vincenzo</creatorcontrib><creatorcontrib>Pepe, Alessia</creatorcontrib><creatorcontrib>Rossi, Giuseppe</creatorcontrib><creatorcontrib>Dell'Amico, MariaChiara</creatorcontrib><creatorcontrib>Salvatori, Cristina</creatorcontrib><creatorcontrib>Keilberg, Petra</creatorcontrib><creatorcontrib>Filosa, Aldo</creatorcontrib><creatorcontrib>Sallustio, Giuseppina</creatorcontrib><creatorcontrib>Midiri, Massimo</creatorcontrib><creatorcontrib>D'Ascola, Domenico</creatorcontrib><creatorcontrib>Santarelli, Maria Filomena</creatorcontrib><creatorcontrib>Lombardi, Massimo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meloni, Antonella</au><au>Positano, Vincenzo</au><au>Pepe, Alessia</au><au>Rossi, Giuseppe</au><au>Dell'Amico, MariaChiara</au><au>Salvatori, Cristina</au><au>Keilberg, Petra</au><au>Filosa, Aldo</au><au>Sallustio, Giuseppina</au><au>Midiri, Massimo</au><au>D'Ascola, Domenico</au><au>Santarelli, Maria Filomena</au><au>Lombardi, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preferential patterns of myocardial iron overload by multislice multiecho T2 CMR in thalassemia major patients</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2010-07</date><risdate>2010</risdate><volume>64</volume><issue>1</issue><spage>211</spage><epage>219</epage><pages>211-219</pages><issn>0740-3194</issn><issn>1522-2594</issn><eissn>1522-2594</eissn><abstract>T*2 multislice multiecho cardiac MR allows quantification of the segmental distribution of myocardial iron overload. This study aimed to determine if there were preferential patterns of myocardial iron overload in thalassemia major. Five hundred twenty‐three thalassemia major patients underwent cardiac MR. Three short‐axis views of the left ventricle were acquired and analyzed using a 16‐segment standardized model. The T*2 value on each segment was calculated, as well as the global value. Four main circumferential regions (anterior, septal, inferior, and lateral) were defined. Significant segmental variability was found in the 229 patients with significant myocardial iron overload (global T*2 <26 ms), subsequently divided into two groups: severe (global T*2 <10 ms) and mild to moderate (global T*2 between 10 and 26 ms) myocardial iron overload. A preferential pattern of iron store in anterior and inferior regions was detected in both groups. This pattern was preserved among the slices. The pattern could not be explained by additive susceptibility artifacts, negligible in heavily iron‐loaded patients. A significantly higher T*2 value in the basal slice was found in patients with severe iron overload. In conclusion, a segmental T*2 cardiac MR approach could identify early iron deposit, useful for tailoring chelation therapy and preventing myocardial dysfunction in the clinical setting. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20572148</pmid><doi>10.1002/mrm.22410</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult beta-Thalassemia - pathology cardiovascular magnetic resonance Child Female Heart - diagnostic imaging Humans Iron Overload - diagnostic imaging Magnetic Resonance Imaging Male Middle Aged multislice multiecho T2 myocardial iron overload Myocardium - pathology preferential pattern Radiography Retrospective Studies thalassemia major |
| title | Preferential patterns of myocardial iron overload by multislice multiecho T2 CMR in thalassemia major patients |
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