high-osmolarity glycerol (HOG) and cell wall integrity (CWI) signalling pathways interplay: a yeast dialogue between MAPK routes

Two mitogen-activated protein kinase (MAPK) pathways, viz. the high-osmolarity glycerol (HOG) and the cell wall integrity (CWI) pathways, regulate stress responses in the yeast Saccharomyces cerevisiae. Whereas the former is mainly involved in adaptation of yeast cells to hyperosmotic stress, the la...

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Bibliographic Details
Published in:Yeast (Chichester, England) England), 2010-08, Vol.27 (8), p.495-502
Main Authors: Rodríguez-Peña, Jose Manuel, García, Raúl, Nombela, César, Arroyo, Javier
Format: Article
Language:English
Subjects:
Cell Wall - metabolism
Cell Wall - physiology
cell wall integrity
CWI pathway
Fungal Proteins - metabolism
Gene Expression Regulation, Fungal
Glycerol - metabolism
HOG pathway
MAP Kinase Signaling System
MAPK
Osmotic Pressure
Saccharomyces cerevisiae
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - physiology
signal transduction
Stress, Physiological
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Summary:Two mitogen-activated protein kinase (MAPK) pathways, viz. the high-osmolarity glycerol (HOG) and the cell wall integrity (CWI) pathways, regulate stress responses in the yeast Saccharomyces cerevisiae. Whereas the former is mainly involved in adaptation of yeast cells to hyperosmotic stress, the latter is activated under conditions leading to cell wall instability. Although MAPK signalling specificity can be conceived as requiring insulation of the different pathways, it is also becoming clear that the two pathways do not compete with each other but can be positively coordinated to regulate many stress responses. This review highlights our current knowledge about the collaboration between these two MAPK pathways to counteract different kinds of environmental stress. Copyright © 2010 John Wiley & Sons, Ltd.
ISSN:0749-503X
1097-0061
1097-0061
DOI:10.1002/yea.1792