Application of aluminum phthalocyanine nanoparticles for fluorescent diagnostics in dentistry and skin autotransplantology

This paper deals with the possibility of application of aluminum phthalocyanine (AlPc) nanoparticles in clinical practice. AlPc fluoresces in the molecular form but in the form of nanoparticles it does not. Separation of molecules from an AlPc nanoparticle and therefore the appearance of fluorescenc...

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Bibliographic Details
Published in:Journal of biophotonics 2010-06, Vol.3 (5-6), p.336-346
Main Authors: Vasilchenko, Sergey Yu, Volkova, Anna I., Ryabova, Anastasiya V., Loschenov, Victor B., Konov, Vitaly I., Mamedov, Adil A., Kuzmin, Sergey G., Lukyanets, Evgeniy A.
Format: Article
Language:English
Subjects:
aluminum phthalocyanine
Animals
autografting
Colloids - chemistry
Dental Enamel - pathology
Dentistry - methods
Dermatologic Surgical Procedures
Female
Fluorescence
fluorescence diagnostics
Graft Rejection - diagnosis
Humans
In Vitro Techniques
Indoles - chemistry
Inflammation - diagnosis
Light
Metal Nanoparticles - chemistry
Mice
nanoparticles
Organometallic Compounds - chemistry
photodynamic therapy
Risk Factors
Scattering, Radiation
Skin - pathology
Skin Transplantation
Solutions
Spectrometry, Fluorescence
Time Factors
tooth enamel
Transplantation, Autologous
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Summary:This paper deals with the possibility of application of aluminum phthalocyanine (AlPc) nanoparticles in clinical practice. AlPc fluoresces in the molecular form but in the form of nanoparticles it does not. Separation of molecules from an AlPc nanoparticle and therefore the appearance of fluorescence occurs under the effect of a number of biochemo‐physical factors. Owing to this feature the application of AlPc nanoparticles followed by the measurement of fluorescence spectra is proposed as a diagnostics method. It was shown that after AlPc nanoparticle application on a tooth surface the fluorescence intensity in the enamel microdamage area is 2–3 times higher than that in the normal enamel area. The appearance of fluorescence after application of AlPc nanoparticles on skin autografts testifies to the presence of inflammation. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
ISSN:1864-063X
1864-0648
1864-0648
DOI:10.1002/jbio.200900099