A novel phase and frequency navigator for proton magnetic resonance spectroscopy using water-suppression cycling

Magnetic resonance spectroscopy is sensitive to movements, in part, because of motion‐induced phase and frequency variations that lead to incoherent averaging. For in vivo proton magnetic resonance spectroscopy, the unsuppressed or under‐suppressed water signal can be used to restore coherent averag...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2011-01, Vol.65 (1), p.13-17
Main Authors: Ernst, Thomas, Li, Jikun
Format: Article
Language:English
Subjects:
Adult
Algorithms
Biopolymers - analysis
Brain - metabolism
Data Interpretation, Statistical
Humans
Least-Squares Analysis
Magnetic Resonance Spectroscopy - methods
motion
MR spectroscopy
navigator
Protons
Reproducibility of Results
Sensitivity and Specificity
Water - analysis
water suppression
water suppression
motion
navigator
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Summary:Magnetic resonance spectroscopy is sensitive to movements, in part, because of motion‐induced phase and frequency variations that lead to incoherent averaging. For in vivo proton magnetic resonance spectroscopy, the unsuppressed or under‐suppressed water signal can be used to restore coherent averaging; however, this approach results in baseline distortions due to the large water peak. Therefore, a novel water‐suppression cycling scheme was developed that alternates between positive and negative residual water signal. Using the residual water signal, the method allows for shot‐to‐shot phase and frequency correction of individual free induction decays and restoration of signal losses due to incoherent averaging, yet near‐complete elimination of residual water. It is demonstrated that the residual water signal can be used to restore metabolite peaks in a brain spectrum from a subject who performed intentional head movements. The ability to correct phase and frequency fluctuations during subject motion is vital for use with adaptive motion correction approaches that ensure proper voxel positioning during head movements. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.22582